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Windows-of-Susceptibility (WS)

The WS thematic area studies the critical windows-of-susceptibility affected by environmental exposures e.g. endocrine disrupting chemicals (EDCs): Bisphenol A, phthalates, perfluoroalkyl substances and obesogens  and the adverse outcomes that lead to health effects later in life. WS team members are interested in genetic imprinting, transgenerational effects, metabolic disorders and pre-term birth that can result from these exposures as well as the developmental origins of health & disease. The Thematic Area is led by Marisa Bartolomei, PhD (Professor of Cell & Developmental Biology , Co-Director Penn Epigenetics Institute & Penn Center for the Study of Epigenetics in Reproduction) . The WS works with the Community Engagement Core to reduce these exposures in critical windows of susceptibility and is conducting studies on the association of air-pollution and adverse birth outcomes in a project called “Geobirth.” Several of the WS investigators also belong to the Center for Research in Reproduction and Women’s Health (CRRWH).

Windows-of-Susceptibility

Marisa Bartolomei, PhD (Leader)

Research Interest: DNA Methylation and Gene Imprinting

Mary Boland, PhD

Research Interest: Prenatal/perinatal Development and Environmental Exposures

Heather Burris, MD

Research Interest:  Social and Environmental Influences on Birth Outcomes

Aimin Chen, MD, PhD

Research Interest: Environmental Epidemiology, Perinatal and Pediatric Epidemiology

Colin Conine, PhD

Research Interest: Exposure of Neonates to Endocrine Disrupting Chemicals in the NICU

William Gaynor, MD

Research Interest: Exposure of Neonates to Endocrine Disrupting Chemicals in the NICU

David A. Hill, MD, PhD

Research Interest: Genetic, Molecular, and Immunologic Origins of Allergy and Obesity

Marilyn Howarth, MD

Research Interest: Community Engagement

Dan (Dongeun) Huh, PhD

Research Interest: Lung-on-a- Chip Models for Human Disease

A. T. Charlie Johnson, PhD

Research Interest: Graphene-Aptamer Chemosensors for Water Contaminants

Yu-Chin Lien, PhD

Research Interest: Epigenetic Modifications on Developmental Origin of Adult Diseases

Krithika Lingappan, MD, PhD, MS

Research Interest: Molecular Mechanisms Underlying the Effect of Environmental Exposures and Outcomes

Katherine Nathanson, MD

Research Interest: Genetic Susceptibility Testicular Germ Cell Tumors

Michael A. Pack, MD

Research Interest: Genetic Screens of 21st TOX Compound Libraries in Zebra Fish

Samuel Parry, MD

Research Interest: Environmental Triggers of Preterm Birth

Trevor Penning, PhD

Research Interest: Human-Aldo Reductase (AKR) Genes in Hormonal and Chemical Carcinogenesis

Sara Pinney, MD, MS

Research Interest: Developmental Origins of Adult Diseases Such as Diabetes and Obesity

Jessica Rice, DO, MHS

Research Interest: Effect of Indoor Fine Particulate Matter Exposure on Respiratory Health Outcomes in Premature Infants

Kotaro Sasaki, MD, PhD

Research Interest: Development of Adrenal Gland in embryo

Enrique Schisterman, PhD, MA

Research Interest: Methodological Components of Exposure Assessment and the Etiologic Study of Reproduction to Improve Reproductive Function

Rebecca Simmons, MD

Research Interest: Developmental Origins of Adult Diseases

Nathaniel Snyder, PhD, MPH

Research Interest: Exposure Science and Environmental Contributions to Autism Spectrum Disorder

Jerome Strauss, MD, PhD

Research Interest: Pre-term Birth and Polycystic Ovarian Syndrome

Aalim Weljie, PhD  

Research Interest: Metabolomics and the Genome

Rebecca Wells, MD

Research Interest: Environmental Exposures and Biliary Atresia

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