Publications

EXPOSURE SCIENCE

Patel CJ, Kerr J, Thomas DC, Mukherjee B, Ritz B, Chatterjee N, Jankowska MM, Madan J, Karagas MR, McAllister KA, Mechanic LE, Fallin MD, Ladd-Acosta C, Blair IA, Teiltelbaum SL, Amos CI. Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies. Cancer Epidemiol Biomarkers Prev. 2017 Jul 14. pii: cebp.0459.2017. doi: 10.1158/1055-9965.EPI-17-0459. [Epub ahead of print] PubMed PMID: 28710076.

Dornhof R, Maschowski C, Osipova A, Gieré R, Seidl M, Merfort I, Humar M. Stress fibers, autophagy and necrosis by persistent exposure to PM2.5 from biomass combustion. PLoS One. 2017 Jul 3;12(7):e0180291. doi:10.1371/journal.pone.0180291. eCollection 2017. PubMed PMID: 28671960; PubMed Central PMCID: PMC5495337.

Jemielita T, Gerton GL, Neidell M, Chillrud S, Yan B, Stute M, Howarth M, Saberi P, Fausti N, Penning TM, Roy J, Propert KJ, Panettieri RA Jr. Unconventional Gas and Oil Drilling Is Associated with Increased Hospital Utilization Rates. PLoS One. 2015 Jul 15;10(7):e0131093. doi:10.1371/journal.pone.0131093. eCollection 2015. Erratum in: PLoS One. 2015;10(8):e0137371. PubMed PMID: 26176544; PubMed Central PMCID: PMC4503720.

Goetz JD, Floerchinger C, Fortner EC, Wormhoudt J, Massoli P, Knighton WB, Herndon SC, Kolb CE, Knipping E, Shaw SL, DeCarlo PF. Atmospheric emission characterization of Marcellus shale natural gas development sites. Environ Sci Technol. 2015 Jun 2;49(11):7012-20. doi: 10.1021/acs.est.5b00452. Epub 2015 May 19. PubMed PMID: 25897974.

Jemielita T, Gerton GL, Neidell M, Chillrud S, Yan B, Stute M, Howarth M, Saberi P, Fausti N, Penning TM, Roy J, Propert KJ, Panettieri RA Jr. Correction: Unconventional Gas and Oil Drilling Is Associated with Increased Hospital Utilization Rates. PLoS One. 2015 Aug 28;10(8):e0137371. doi: 10.1371/journal.pone.0137371. eCollection 2015. PubMed PMID: 26317358; PubMed Central PMCID: PMC4552724.

Mohr C, DeCarlo PF, Heringa MF, Chirico R, Richter R, Crippa M, Querol X, Baltensperger U, Prévôt AS. Correction to Spatial Variation of Aerosol Chemical Composition and Organic Components Identified by Positive Matrix Factorization in the Barcelona Region. Environ Sci Technol. 2016 Mar 1;50(5):2743. doi:10.1021/acs.est.6b00449. Epub 2016 Feb 11. PubMed PMID: 26866672.

Johnson AM, Waring MS, DeCarlo PF. Real-time transformation of outdoor aerosol components upon transport indoors measured with aerosol mass spectrometry. Indoor Air. 2016 Mar 23. doi: 10.1111/ina.12299. [Epub ahead of print] PubMed PMID: 27008502.

Huang M, Mesaros C, Zhang S, Blair IA, Penning TM. Potential Metabolic Activation of a Representative C2-Alkylated Polycyclic Aromatic Hydrocarbon 6-Ethylchrysene Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells. Chem Res Toxicol. 2016 Jun 20;29(6):991-1002. doi: 10.1021/acs.chemrestox.6b00036. Epub 2016 May 1. PubMed PMID: 27054409; PubMed Central PMCID: PMC4916485.

AUTISM

Wenger TL, Kao C, McDonald-McGinn DM, Zackai EH, Bailey A, Schultz RT, Morrow BE, Emanuel BS, Hakonarson H. The Role of mGluR Copy Number Variation in Genetic and Environmental Forms of Syndromic Autism Spectrum Disorder. Sci Rep. 2016 Jan 19;6:19372. doi: 10.1038/srep19372. PubMed PMID: 26781481; PubMed Central PMCID: PMC4726047.

Ridge PG, Hoyt KB, Boehme K, Mukherjee S, Crane PK, Haines JL, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD, Kauwe JS; Alzheimer’s Disease Genetics Consortium (ADGC). Assessment of the genetic variance of late-onset Alzheimer’s disease. Neurobiol Aging. 2016 May;41:200.e13-20. doi: 10.1016/j.neurobiolaging.2016.02.024. Epub 2016 Mar 3. PubMed PMID: 27036079; PubMed Central PMCID: PMC4948179.

BIOINFORMATICS

Rohani A, Moore JH, Kashatus JA, Sesaki H, Kashatus DF, Swami NS. Label-Free Quantification of Intracellular Mitochondrial Dynamics Using Dielectrophoresis. Anal Chem. 2017 Jun 6;89(11):5757-5764. doi: 10.1021/acs.analchem.6b04666. Epub 2017 May 15. PubMed PMID: 28475301; PubMed Central PMCID: PMC5463269.

Crabtree NM, Moore JH, Bowyer JF, George NI. Multi-class computational evolution: development, benchmark evaluation and application to RNA-Seq biomarker discovery. BioData Min. 2017 Apr 24;10:13. doi: 10.1186/s13040-017-0134-8. eCollection 2017. PubMed PMID: 28450890; PubMed Central PMCID: PMC5404302.

Ahmed M, Sallari RC, Guo H, Moore JH, He HH, Lupien M. Variant Set Enrichment: an R package to identify disease-associated functional genomic regions. BioData Min. 2017 Feb 22;10:9. doi: 10.1186/s13040-017-0129-5. eCollection 2017. PubMed PMID: 28239419; PubMed Central PMCID: PMC5320724.

Frost HR, Shen L, Saykin AJ, Williams SM, Moore JH; Alzheimer’s Disease Neuroimaging Initiative. Identifying significant gene-environment interactions using a combination of screening testing and hierarchical false discovery rate control. Genet Epidemiol. 2016 Nov;40(7):544-557. doi: 10.1002/gepi.21997. Epub 2016 Aug 31. PubMed PMID: 27578615; PubMed Central PMCID: PMC5108431.

Yao X, Yan J, Kim S, Nho K, Risacher SL, Inlow M, Moore JH, Saykin AJ, Shen L. Two-dimensional enrichment analysis for mining high-level imaging genetic associations. Brain Inform. 2017 Mar;4(1):27-37. doi: 10.1007/s40708-016-0052-4. Epub 2016 May 13. PubMed PMID: 27747820; PubMed Central PMCID: PMC5118198.

Frost HR, Amos CI, Moore JH. A global test for gene-gene interactions based  on random matrix theory. Genet Epidemiol. 2016 Jul 7. doi: 10.1002/gepi.21990.[Epub ahead of print] PubMed PMID: 27386793.

Moore JH, Holmes JH. The golden era of biomedical informatics has begun. BioData Min. 2016 Apr 11;9:15. doi: 10.1186/s13040-016-0092-6. eCollection 2016. PubMed PMID: 27069509; PubMed Central PMCID: PMC4827231.

Qiu J, Moore JH, Darabos C. Studying the Genetics of Complex Disease With Ancestry-Specific Human Phenotype Networks: The Case of Type 2 Diabetes in East Asian Populations. Genet Epidemiol. 2016 May;40(4):293-303. doi:10.1002/gepi.21964. Epub 2016 Apr 7. PubMed PMID: 27061195.

Darabos C, Qiu J, Moore JH. AN INTEGRATED NETWORK APPROACH TO IDENTIFYING BIOLOGICAL PATHWAYS AND ENVIRONMENTAL EXPOSURE INTERACTIONS IN COMPLEX DISEASES.  Pac Symp Biocomput. 2016;21:9-20. PubMed PMID: 26776169; PubMed Central PMCID:PMC4721271.

Li H, Achour I, Bastarache L, Berghout J, Gardeux V, Li J, Lee Y, Pesce L, Yang X, Ramos KS, Foster I, Denny JC, Moore JH, Lussier YA. Integrative genomics  analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions. NPJ Genom Med. 2016;1. pii: 16006. Epub 2016 Apr 27. PubMed PMID: 27482468; PubMed Central PMCID: PMC4966659.

Huang M, Graham BE, Zhang G, Harder R, Kodaman N, Moore JH, Muglia L, Williams SM. Evolutionary triangulation: informing genetic association studies with evolutionary evidence. BioData Min. 2016 Apr 2;9:12. doi: 10.1186/s13040-016-0091-7. eCollection 2016. PubMed PMID: 27042214; PubMed Central PMCID: PMC4818851.

Lynch SM, Moore JH. A call for biological data mining approaches in epidemiology. BioData Min. 2016 Jan 4;9:1. doi: 10.1186/s13040-015-0079-8.eCollection 2016. PubMed PMID: 26734074; PubMed Central PMCID: PMC4700596.

Hart SN, Maxwell KN, Thomas T, Ravichandran V, Wubberhorst B, Klein RJ,Schrader K, Szabo C, Weitzel JN, Neuhausen SL, Nathanson K, Offit K, Couch FJ, Vijai J. Collaborative science in the next-generation sequencing era: a viewpoint on how to combine exome sequencing data across sites to identify novel disease susceptibility genes. Brief Bioinform. 2016 Jul;17(4):672-7. doi:10.1093/bib/bbv075. Epub 2015 Sep 10. PubMed PMID: 26358132; PubMed Central PMCID: PMC4945829.

Li J, Malley JD, Andrew AS, Karagas MR, Moore JH. Detecting gene-gene interactions using a permutation-based random forest method. BioData Min. 2016 Apr 6;9:14. doi: 10.1186/s13040-016-0093-5. eCollection 2016. PubMed PMID:27053949; PubMed Central PMCID: PMC4822295.

Darabos C, Qiu J, Moore JH. AN INTEGRATED NETWORK APPROACH TO IDENTIFYING BIOLOGICAL PATHWAYS AND ENVIRONMENTAL EXPOSURE INTERACTIONS IN COMPLEX DISEASES.  Pac Symp Biocomput. 2016;21:9-20. PubMed PMID: 26776169; PubMed Central PMCID:PMC4721271.

Li H, Achour I, Bastarache L, Berghout J, Gardeux V, Li J, Lee Y, Pesce L, Yang X, Ramos KS, Foster I, Denny JC, Moore JH, Lussier YA. Integrative genomics  analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions. NPJ Genom Med. 2016;1. pii: 16006. Epub 2016 Apr 27. PubMed PMID: 27482468; PubMed Central PMCID: PMC4966659.

BIOMARKERS

Mesaros C, Arroyo AD, Blair IA, Snyder NW. Coenzyme A thioester formation of 11- and 15-oxo-eicosatetraenoic acid. Prostaglandins Other Lipid Mediat. 2017 May;130:1-7. doi: 10.1016/j.prostaglandins.2017.02.004. Epub 2017 Feb 24. PubMed PMID: 28238887; PubMed Central PMCID: PMC5446925.

Kulkarni RA, Worth AJ, Zengeya TT, Shrimp JH, Garlick JM, Roberts AM, Montgomery DC, Sourbier C, Gibbs BK, Mesaros C, Tsai YC, Das S, Chan KC, Zhou M, Andresson T, Weissman AM, Linehan WM, Blair IA, Snyder NW, Meier JL. Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling. Cell Chem Biol. 2017 Feb 16;24(2):231-242. doi: 10.1016/j.chembiol.2017.01.002. Epub 2017Feb 2. PubMed PMID: 28163016.

Mesaros C, Blair IA. Mass spectrometry-based approaches to targeted quantitative proteomics in cardiovascular disease. Clin Proteomics. 2016 Oct 5;13:20. eCollection 2016. Review. PubMed PMID: 27713681; PubMed Central PMCID: PMC5050566.

Kim J, Bamlet WR, Oberg AL, Chaffee KG, Donahue G, Cao XJ, Chari S, Garcia BA, Petersen GM, Zaret KS. Detection of early pancreatic ductal adenocarcinoma with thrombospondin-2 and CA19-9 blood markers. Sci Transl Med. 2017 Jul 12;9(398). pii: eaah5583. doi: 10.1126/scitranslmed.aah5583. PubMed PMID: 28701476.

Zang T, Taplin ME, Tamae D, Xie W, Mesaros C, Zhang Z, Bubley G, Montgomery B, Balk SP, Mostaghel EA, Blair IA, Penning TM. Testicular vs adrenal sources of hydroxy-androgens in prostate cancer. Endocr Relat Cancer. 2017 Aug;24(8):393-404. doi: 10.1530/ERC-17-0107. Epub 2017 Jun 29. PubMed PMID: 28663228.

 Zang T, Tamae D, Mesaros C, Wang Q, Huang M, Blair IA, Penning TM. Simultaneous quantitation of nine hydroxy-androgens and their conjugates in human serum by stable isotope dilution liquid chromatography electrospray ionization tandem mass spectrometry. J Steroid Biochem Mol Biol. 2017 Jan;165(Pt B):342-355. doi: 10.1016/j.jsbmb.2016.08.001. Epub 2016 Aug 12. PubMed PMID: 27531846; PubMedCentral PMCID: PMC5146996.

Wang Q, Mesaros C, Blair IA. Ultra-high sensitivity analysis of estrogens for special populations in serum and plasma by liquid chromatography-mass spectrometry: Assay considerations and suggested practices. J Steroid Biochem Mol Biol. 2016 Sep;162:70-9. doi: 10.1016/j.jsbmb.2016.01.002. Epub 2016 Jan 6. Review. PubMed PMID: 26767303; PubMed Central PMCID: PMC4931956.

FitzGerald GA. Measure for Measure: Biomarker standards and transparency. Sci Transl Med. 2016 Jun 15;8(343):343fs10. doi: 10.1126/scitranslmed.aaf8590. Review. PubMed PMID: 27306662.

GENE/ENVIRONMENT INTERACTIONS

Wang S, Huo D, Ogundiran TO, Ojengbede O, Zheng W, Nathanson KL, Nemesure B, Ambs S, Olopade OI, Zheng Y. Association of breast cancer risk and the mTOR pathway in women of African ancestry in “The Root” Consortium. Carcinogenesis. 2017 Jun 5. doi: 10.1093/carcin/bgx055. [Epub ahead of print] PubMed PMID: 28582508. 

Kowal E, Llamas B, Tishkoff S. Consent: Data-sharing for indigenous peoples. Nature. 2017 Jun 21;546(7659):474. doi: 10.1038/546474a. PubMed PMID: 28640268.

Kelly DE, Hasen MEB, Tishkoff SA. Global variation in gene expression and the value of diverse sampling. Curr Opin Syst Biol. 2017 Feb;1:102-108. doi: 10.1016/j.coisb.2016.12.018. Epub 2017 Mar 3. PubMed PMID: 28596996; PubMed Central PMCID: PMC5458633.

Fan S, Hansen ME, Lo Y, Tishkoff SA. Going global by adapting local: A review of recent human adaptation. Science. 2016 Oct 7;354(6308):54-59. Review. PubMed PMID: 27846491; PubMed Central PMCID: PMC5154245.

Feng Y, Rhie SK, Huo D, Ruiz-Narvaez EA, Haddad SA, Ambrosone CB, John EM, Bernstein L, Zheng W, Hu JJ, Ziegler RG, Nyante S, Bandera EV, Ingles SA, Press MF, Deming SL, Rodriguez-Gil JL, Zheng Y, Yao S, Han YJ, Ogundiran TO, Rebbeck TR, Adebamowo C, Ojengbede O, Falusi AG, Hennis A, Nemesure B, Ambs S, Blot W, Cai Q, Signorello L, Nathanson KL, Lunetta KL, Sucheston-Campbell LE, Bensen JT, Chanock SJ, Marchand LL, Olshan AF, Kolonel LN, Conti DV, Coetzee GA, Stram DO, Olopade OI, Palmer JR, Haiman CA. Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry. Cancer Epidemiol Biomarkers Prev. 2017 Jul;26(7):1016-1026. doi: 10.1158/1055-9965.EPI-16-0567. Epub 2017 Apr 4. PubMed PMID: 28377418; PubMed Central PMCID: PMC5500414.

Huo D, Feng Y, Haddad S, Zheng Y, Yao S, Han YJ, Ogundiran TO, Adebamowo C, Ojengbede O, Falusi AG, Zheng W, Blot W, Cai Q, Signorello L, John EM, Bernstein L, Hu JJ, Ziegler RG, Nyante S, Bandera EV, Ingles SA, Press MF, Deming SL, Rodriguez-Gil JL, Nathanson KL, Domchek SM, Rebbeck TR, Ruiz-Narváez EA, Sucheston-Campbell LE, Bensen JT, Simon MS, Hennis A, Nemesure B, Leske MC, Ambs S, Chen LS, Qian F, Gamazon ER, Lunetta KL, Cox NJ, Chanock SJ, Kolonel LN, Olshan AF, Ambrosone CB, Olopade OI, Palmer JR, Haiman CA. Genome-wideassociation studies in women of African ancestry identified 3q26.21 as a novel susceptibility locus for oestrogen receptor negative breast cancer. Hum Mol Genet. 2016 Nov 1;25(21):4835-4846. doi: 10.1093/hmg/ddw305. PubMed PMID:28171663.

Beltrame MH, Rubel MA, Tishkoff SA. Inferences of African evolutionary history from genomic data. Curr Opin Genet Dev. 2016 Dec;41:159-166. doi: 10.1016/j.gde.2016.10.002. Epub 2016 Nov 1. Review. PubMed PMID: 27810637; PubMed Central PMCID: PMC5161638.

Hsieh P, Veeramah KR, Lachance J, Tishkoff SA, Wall JD, Hammer MF, Gutenkunst RN. Whole-genome sequence analyses of Western Central African Pygmy hunter-gatherers reveal a complex demographic history and identify candidate genes under positive natural selection. Genome Res. 2016 Mar;26(3):279-90. doi: 10.1101/gr.192971.115. Epub 2016 Feb 17. PubMed PMID: 26888263; PubMed Central PMCID: PMC4772011.

Stone RC, Horvath K, Kark JD, Susser E, Tishkoff SA, Aviv A. Telomere Length and the Cancer-Atherosclerosis Trade-Off. PLoS Genet. 2016 Jul 7;12(7):e1006144. doi: 10.1371/journal.pgen.1006144. eCollection 2016 Jul. Review. PubMed PMID: 27386863; PubMed Central PMCID: PMC4936693.

Hansen ME, Hunt SC, Stone RC, Horvath K, Herbig U, Ranciaro A, Hirbo J, Beggs W, Reiner AP, Wilson JG, Kimura M, De Vivo I, Chen MM, Kark JD, Levy D, Nyambo T, Tishkoff SA, Aviv A. Shorter telomere length in Europeans than in Africans due to polygenetic adaptation. Hum Mol Genet. 2016 Mar 2. pii: ddw070.[Epub ahead of print] PubMed PMID: 26936823.

Yudell M, Roberts D, DeSalle R, Tishkoff S. SCIENCE AND SOCIETY. Taking race out of human genetics. Science. 2016 Feb Cance5;351(6273):564-5. doi: 10.1126/science.aac4951. PubMed PMID: 26912690. 

ENVIRONMENTAL EXPOSURES & CANCER 

Sterman DH, Alley E, Stevenson JP, Friedberg J, Metzger S, Recio A, Moon EK, Haas AR, Vachani A, Katz SI, Sun J, Heitjan DF, Hwang WT, Litzky L, Yearley JH, Tan KS, Papasavvas E, Kennedy P, Montaner LJ, Cengel KA, Simone CB 2nd, Culligan M, Langer CJ, Albelda SM. Pilot and Feasibility Trial Evaluating Immuno-Gene Therapy of Malignant Mesothelioma Using Intrapleural Delivery of Adenovirus-IFNα Combined with Chemotherapy. Clin Cancer Res. 2016 Aug 1;22(15):3791-800. doi: 10.1158/1078-0432.CCR-15-2133. Epub 2016 Mar 11. PubMed PMID: 26968202; PubMed Central PMCID: PMC4970934.

Kadariya Y, Menges CW, Talarchek J, Cai KQ, Klein-Szanto AJ, Pietrofesa RA, Christofidou-Solomidou M, Cheung M, Mossman BT, Shukla A, Testa JR. Inflammation-Related IL1β/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma. Cancer Prev Res (Phila). 2016 May;9(5):406-14. doi: 10.1158/1940-6207.CAPR-15-0347. Epub 2016 Mar 2. PubMed PMID: 26935421; PubMed Central PMCID: PMC4854753.

Ohar JA, Cheung M, Talarchek J, Howard SE, Howard TD, Hesdorffer M, Peng H, Rauscher FJ, Testa JR. Germline BAP1 Mutational Landscape of Asbestos-Exposed Malignant Mesothelioma Patients with Family History of Cancer. Cancer Res. 2016 Jan 15;76(2):206-15. doi: 10.1158/0008-5472.CAN-15-0295. Epub 2015 Dec 30. PubMed PMID: 26719535; PubMed Central PMCID: PMC4715907.

Pietrofesa RA, Velalopoulou A, Albelda SM, Christofidou-Solomidou M. Asbestos Induces Oxidative Stress and Activation of Nrf2 Signaling in Murine Macrophages: Chemopreventive Role of the Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605). Int J Mol Sci. 2016 Mar 1;17(3):322. doi: 10.3390/ijms17030322. PubMed PMID: 26938529; PubMed Central PMCID: PMC4813184.

Kadariya Y, Cheung M, Xu J, Pei J, Sementino E, Menges CW, Cai KQ, Rauscher FJ, Klein-Szanto AJ, Testa JR. Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations. Cancer Res. 2016 May 1;76(9):2836-44. doi: 10.1158/0008-5472.CAN-15-3371. Epub 2016 Feb 19. PubMed PMID: 26896281; PubMed Central PMCID: PMC4873414.

Pietrofesa RA, Velalopoulou A, Arguiri E, Menges CW, Testa JR, Hwang WT, Albelda SM, Christofidou-Solomidou M. Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice. Carcinogenesis. 2016 Feb;37(2):177-87. doi: 10.1093/carcin/bgv174. Epub 2015 Dec 17. PubMed PMID: 26678224; PubMed Central PMCID: PMC4745643.

Borczuk AC, Pei J, Taub RN, Levy B, Nahum O, Chen J, Chen K, Testa JR. Genome-wide analysis of abdominal and pleural malignant mesothelioma with DNA arrays reveals both common and distinct regions of copy number alteration. Cancer Biol Ther. 2016;17(3):328-35. doi: 10.1080/15384047.2016.1145850. Epub 2016 Feb 6. PubMed PMID: 26853494; PubMed Central PMCID: PMC4847993.

Huang M, Mesaros C, Hackfeld LC, Hodge RP, Zang T, Blair IA, Penning TM. Potential Metabolic Activation of a Representative C4-Alkylated Polycyclic Aromatic Hydrocarbon Retene (1-Methyl-7-isopropyl-phenanthrene) Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells. Chem Res Toxicol. 2017 Apr 17;30(4):1093-1101. doi: 10.1021/acs.chemrestox.6b00457. Epub 2017 Mar 22. PubMed PMID: 28278373.

Chikara S, Lindsey K, Borowicz P, Christofidou-Solomidou M, Reindl KM. Enterolactone alters FAK-Src signaling and suppresses migration and invasion of lung cancer cell lines. BMC Complement Altern Med. 2017 Jan 9;17(1):30. doi: 10.1186/s12906-016-1512-3. PubMed PMID: 28068967; PubMed Central PMCID: PMC5223372.

Cooke M, Magimaidas A, Casado-Medrano V, Kazanietz MG. Protein kinase C in cancer: The top five unanswered questions. Mol Carcinog. 2017 Jun;56(6):1531-1542. doi: 10.1002/mc.22617. Epub 2017 Mar 10. PubMed PMID: 28112438; PubMed Central PMCID: PMC5423816.

Wang Z, McGlynn KA, Rajpert-De Meyts E, Bishop DT, Chung CC, Dalgaard MD, Greene MH, Gupta R, Grotmol T, Haugen TB, Karlsson R, Litchfield K, Mitra N, Nielsen K, Pyle LC, Schwartz SM, Thorsson V, Vardhanabhuti S, Wiklund F, Turnbull C, Chanock SJ, Kanetsky PA, Nathanson KL; Testicular Cancer Consortium. Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor. Nat Genet. 2017 Jul;49(7):1141-1147. doi: 10.1038/ng.3879. Epub 2017 Jun 12. PubMed PMID:28604732; PubMed Central PMCID: PMC5490654.

Kuchenbaecker KB, McGuffog L, Barrowdale D, Lee A, Soucy P, Dennis J, Domchek SM, Robson M, Spurdle AB, Ramus SJ, Mavaddat N, Terry MB, Neuhausen SL,Schmutzler RK, Simard J, Pharoah PDP, Offit K, Couch FJ, Chenevix-Trench G,Easton DF, Antoniou AC, Lush M, Hamann U, Southey M, John EM, Chung WK, Daly MB, Buys SS, Goldgar DE, Dorfling CM, van Rensburg EJ, Chun Ding Y, Ejlertsen B, Gerdes AM, Hansen TV, Slager S, Hallberg E, Benitez J, Osorio A, Cohen N, Lawler W, Weitzel JN, Peterlongo P, Pensotti V, Dolcetti R, Barile M, Bonanni B, Azzollini J, Manoukian S, Peissel B, Radice P, Savarese A, Papi L, Giannini G, Fostira F, Konstantopoulou I, Adlard J, Brewer C, Cook J, Davidson R, Eccles D, Eeles R, Ellis S, Frost D, Hodgson S, Izatt L, Lalloo F, Ong KR, Godwin AK, Arnold N, Dworniczak B, Engel C, Gehrig A, Hahnen E, Hauke J, Kast K, Meindl A, Niederacher D, Schmutzler RK, Varon-Mateeva R, Wang-Gohrke S, Wappenschmidt B, Barjhoux L, Collonge-Rame MA, Elan C, Golmard L; GEMO Study Collaborators; EMBRACE, Barouk-Simonet E, Lesueur F, Mazoyer S, Sokolowska J, Stoppa-Lyonnet D, Isaacs C, Claes KBM, Poppe B, de la Hoya M, Garcia-Barberan V, Aittomaki K, Nevanlinna H, Ausems MGEM, de Lange JL, Gomez Garcia EB, Hogervorst FB; HEBON, Kets CM, Meijers-Heijboer HE, Oosterwijk JC, Rookus MA, van Asperen CJ, van den Ouweland AMW, van Doorn HC, van Os TAM, Kwong A, Olah E, Diez O, Brunet J, Lazaro C, Teule A, Gronwald J, Jakubowska A, Kaczmarek K, Lubinski J, Sukiennicki G, Barkardottir RB, Chiquette J, Agata S, Montagna M, Teixeira MR, Kyung Park S; KConFab Investigators, Olswold C, Tischkowitz M, Foretova L, Gaddam P, Vijai J, Pfeiler G, Rappaport-Fuerhauser C, Singer CF, Tea MKM, Greene MH, Loud JT, Rennert G, Imyanitov EN, Hulick PJ, Hays JL, Piedmonte M, Rodriguez GC, Martyn J, Glendon G, Mulligan AM, Andrulis IL, Toland AE, Jenson UB, Kruse TA, Sokilde Pedersen I, Thomassen M, Caligo MA, Teo SH, Berger R, Friedman E, Laitman Y, Arver B, Borg A, Ehrancrona H, Rantala J, Olopade OI, Ganz PA, Nussbaum RL, Bradbury AR, Domchek SM, Nathanson KL, Arun BK, James P, Karlan BY, Lester J, Simard J, Pharoah PDP, Offit K, Couch FJ, Chenevix-Trench G, Easton DF, Antoniou. Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers. J Natl Cancer Inst. 2017 Jul 1;109(7). doi: 10.1093/jnci/djw302. PubMed PMID: 28376175; PubMed Central PMCID: PMC5408990.

Cicchini M, Buza EL, Sagal KM, Gudiel AA, Durham AC, Feldser DM. Context-Dependent Effects of Amplified MAPK Signaling during Lung Adenocarcinoma  Initiation and Progression. Cell Rep. 2017 Feb 21;18(8):1958-1969. doi:10.1016/j.celrep.2017.01.069. PubMed PMID: 28228261; PubMed Central PMCID:PMC5405440.

Baker MJ, Cooke M, Kazanietz MG. Nuclear PKCι-ECT2-Rac1 and Ribosome Biogenesis: A Novel Axis in Lung Tumorigenesis. Cancer Cell. 2017 Feb 13;31(2):167-169. doi: 10.1016/j.ccell.2017.01.008. PubMed PMID: 28196591.

Kennedy GT, Okusanya OT, Keating JJ, Heitjan DF, Deshpande C, Litzky LA, Albelda SM, Drebin JA, Nie S, Low PS, Singhal S. The Optical Biopsy: A Novel Technique for Rapid Intraoperative Diagnosis of Primary Pulmonary Adenocarcinomas. Ann Surg. 2015 Oct;262(4):602-9. doi:10.1097/SLA.0000000000001452. PubMed PMID: 26366539.

Vachani A, Whitney DH, Parsons EC, Lenburg M, Ferguson JS, Silvestri GA, Spira A. Clinical Utility of a Bronchial Genomic Classifier in Patients With Suspected Lung Cancer. Chest. 2016 Jul;150(1):210-8. doi: 10.1016/j.chest.2016.02.636. Epub 2016 Feb 16. PubMed PMID: 26896702.

Vachani A, Jett JR. Screening for Lung Cancer. Improving Outcomes with Better Patient Selection. Am J Respir Crit Care Med. 2016 Mar 1;193(5):478-9. doi: 10.1164/rccm.201510-2096ED. PubMed PMID: 26930429. Abera MB, Kazanietz MG. Protein kinase Cα mediates erlotinib resistance in lung cancer cells. Mol Pharmacol. 2015 May;87(5):832-41. doi: 10.1124/mol.115.097725. Epub 2015 Feb 27. PubMed PMID: 25724832; PubMed Central PMCID: PMC4407729.

Zanetti KA, Wang Z, Aldrich M, Amos CI, Blot WJ, Bowman ED, Burdette L, Cai Q, Caporaso N, Chung CC, Gillanders EM, Haiman CA, Hansen HM, Henderson BE, Kolonel LN, Marchand LL, Li S, McNeill LH, Ryan BM, Schwartz AG, Sison JD, Spitz MR, Tucker M, Wenzlaff AS, Wiencke JK, Wilkens L, Wrensch MR, Wu X, Zheng W, Zhou W, Christiani D, Palmer JR, Penning TM, Rieber AG, Rosenberg L, Ruiz-Narvaez EA, Su L, Vachani A, Wei Y, Whitehead AS, Chanock SJ, Harris CC. Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. Lung Cancer. 2016 Aug;98:33-42. doi: 10.1016/j.lungcan.2016.05.008. Epub 2016 May 13. PubMed PMID: 27393504; PubMed Central PMCID: PMC4939239.

Whitney DH, Elashoff MR, Porta-Smith K, Gower AC, Vachani A, Ferguson JS, Silvestri GA, Brody JS, Lenburg ME, Spira A. Derivation of a bronchial genomic classifier for lung cancer in a prospective study of patients undergoing diagnostic bronchoscopy. BMC Med Genomics. 2015 May 6;8:18. doi: 10.1186/s12920-015-0091-3. PubMed PMID: 25944280; PubMed Central PMCID: PMC4434538.

Xu R, Mesaros C, Weng L, Snyder NW, Vachani A, Blair IA, Hwang WT. Comparison  of statistical methods for detection of serum lipid biomarkers for mesothelioma and asbestos exposure. Biomark Med. 2017 Jul;11(7):547-556. doi: 10.2217/bmm-2017-0087. Epub 2017 May 23. PubMed PMID: 28534416.

Cheung M, Testa JR. BAP1, a tumor suppressor gene driving malignant mesothelioma. Transl Lung Cancer Res. 2017 Jun;6(3):270-278. doi: 10.21037/tlcr.2017.05.03. Review. PubMed PMID: 28713672; PubMed Central PMCID: PMC5504107.

EPIGENETICS 

Sidoli S, Garcia BA. Middle-down proteomics: a still unexploited resource for chromatin biology. Expert Rev Proteomics. 2017 Jul;14(7):617-626. doi: 10.1080/14789450.2017.1345632. Epub 2017 Jun 28. PubMed PMID: 28649883.

Feist PE, Sidoli S, Liu X, Schroll MM, Rahmy S, Fujiwara R, Garcia BA, Hummon Multicellular Tumor Spheroids Combined with Mass Spectrometric Histone Analysis To Evaluate Epigenetic Drugs. Anal Chem. 2017 Mar 7;89(5):2773-2781. doi: 10.1021/acs.analchem.6b03602. Epub 2017 Feb 21. PubMed PMID: 28194967; PubMed Central PMCID: PMC5371507.

Cao XJ, Garcia BA. Global Proteomics Analysis of Protein Lysine Methylation. Curr Protoc Protein Sci. 2016 Nov 1;86:24.8.1-24.8.19. doi: 10.1002/cpps.16.  PubMed PMID: 27801517; PubMed Central PMCID: PMC5222891.

Hur SK, Freschi A, Ideraabdullah F, Thorvaldsen JL, Luense LJ, Weller AH, Berger SL, Cerrato F, Riccio A, Bartolomei MS. Humanized H19/Igf2 locus reveals diverged imprinting mechanism between mouse and human and reflects Silver-Russell syndrome phenotypes. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10938-43. doi: 10.1073/pnas.1603066113. Epub 2016 Sep 12. PubMed PMID: 27621468; PubMed Central PMCID: PMC5047210.

Zhu J, Dou Z, Sammons MA, Levine AJ, Berger SL. Lysine methylation represses p53 activity in teratocarcinoma cancer cells. Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9822-7. doi: 10.1073/pnas.1610387113. Epub 2016 Aug 17. PubMed PMID: 27535933; PubMed Central PMCID: PMC5024588.

Berger SL, Sassone-Corsi P. Metabolic Signaling to Chromatin. Cold Spring Harb Perspect Biol. 2016 Nov 1;8(11). pii: a019463. doi: 10.1101/cshperspect.a019463. Review. PubMed PMID: 26492570.

 Bonini NM, Berger SL. The Sustained Impact of Model Organisms-in Genetics and Epigenetics. Genetics. 2017 Jan;205(1):1-4. doi: 10.1534/genetics.116.187864. PubMed PMID: 28049700; PubMed Central PMCID: PMC5223495.

Sidoli S, Garcia BA. Characterization of Individual Histone Posttranslational Modifications and Their Combinatorial Patterns by Mass Spectrometry-Based Proteomics Strategies. Methods Mol Biol. 2017;1528:121-148. PubMed PMID: 27854019; PubMed Central PMCID: PMC5240223.

Sidoli S, Lu C, Coradin M, Wang X, Karch KR, Ruminowicz C, Garcia BA. Metabolic labeling in middle-down proteomics allows for investigation of the dynamics of the histone code. Epigenetics Chromatin. 2017 Jul 6;10(1):34. doi: 10.1186/s13072-017-0139-z. PubMed PMID: 28683815; PubMed Central PMCID: PMC5501349.

Ginart P, Kalish JM, Jiang CL, Yu AC, Bartolomei MS, Raj A. Visualizing allele-specific expression in single cells reveals epigenetic mosaicism in an H19 loss-of-imprinting mutant. Genes Dev. 2016 Mar 1;30(5):567-78. doi: 10.1101/gad.275958.115. PubMed PMID: 26944681; PubMed Central PMCID: PMC4782050.

Ma P, de Waal E, Weaver JR, Bartolomei MS, Schultz RM. A DNMT3A2-HDAC2 Complex Is Essential for Genomic Imprinting and Genome Integrity in Mouse Oocytes. Cell Rep. 2015 Nov 24;13(8):1552-60. doi: 10.1016/j.celrep.2015.10.031.  Epub 2015 Nov 12. PubMed PMID: 26586441; PubMed Central PMCID: PMC4662907.

Sen P, Shah PP, Nativio R, Berger SL. Epigenetic Mechanisms of Longevity and Aging. Cell. 2016 Aug 11;166(4):822-39. doi: 10.1016/j.cell.2016.07.050. Review.  PubMed PMID: 27518561.

Berger SL, Adams PD. Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability. Genome Biol. 2016 Jul 25;17(1):158. doi: 10.1186/s13059-016-1017-x. PubMed PMID: 27457071; PubMed Central PMCID: PMC4960804.

ORGAN-ON-A-CHIP

Huh DD, Kim DH. JALA special issue: microengineered cell- and tissue-based assays for drug screening and toxicology applications. J Lab Autom. 2015 Apr;20(2):79-81. Doi: 10.1177/2211068215574458. PubMed PMID: 25795434.

WINDOWS-OF-SUSCEPTIBILITY

Sathyanarayana S, Butts S, Wang C, Barrett E, Nguyen R, Schwartz SM, Haaland W, Swan SH; TIDES Team. Early Prenatal Phthalate Exposure, Sex Steroid Hormones,  and Birth Outcomes. J Clin Endocrinol Metab. 2017 Jun 1;102(6):1870-1878. doi:10.1210/jc.2016-3837. PubMed PMID: 28324030; PubMed Central PMCID: PMC5470772.

Mafra F, Mazzotti D, Pellegrino R, Bianco B, Barbosa CP, Hakonarson H, Christofolini D. Copy number variation analysis reveals additional variants contributing to endometriosis development. J Assist Reprod Genet. 2017 Jan;34(1):117-124. doi: 10.1007/s10815-016-0822-1. Epub 2016 Nov 5. PubMed PMID: 27817035; PubMed Central PMCID: PMC5330977.

Pinney SE, Mesaros CA, Snyder NW, Busch CM, Xiao R, Aijaz S, Ijaz N, Blair IA, Manson JM. Second trimester amniotic fluid bisphenol A concentration is associated with decreased birth weight in term infants. Reprod Toxicol. 2017 Jan;67:1-9. doi: 10.1016/j.reprotox.2016.11.007. Epub 2016 Nov 6. PubMed PMID: 27829162; PubMed Central PMCID: PMC5303174.

Lessing D, Dial TO, Wei C, Payer B, Carrette LL, Kesner B, Szanto A, Jadhav A, Maloney DJ, Simeonov A, Theriault J, Hasaka T, Bedalov A, Bartolomei MS, Lee JT. A high-throughput small molecule screen identifies synergism between DNAmethylation and Aurora kinase pathways for X reactivation. Proc Natl Acad Sci U S 2016 Dec 13;113(50):14366-14371. doi: 10.1073/pnas.1617597113. Epub 2016 Nov PubMed PMID: 28182563; PubMed Central PMCID: PMC5167172.

Vrooman LA, Bartolomei MS. Can assisted reproductive technologies cause adult-onset disease? Evidence from human and mouse. Reprod Toxicol. 2017 Mar;68:72-84. doi: 10.1016/j.reprotox.2016.07.015. Epub 2016 Jul 26. PubMed PMID: 27474254; PubMed Central PMCID: PMC5269604.

Susiarjo M, Xin F, Stefaniak M, Mesaros C, Simmons RA, Bartolomei MS. Bile acids and tryptophan metabolism are novel pathways involved in metabolic abnormalities in BPA-exposed pregnant mice and male offspring. Endocrinology. 2017 May 25. doi: 10.1210/en.2017-00046. [Epub ahead of print] PubMed PMID: 28549143.

Ghosh J, Mainigi M, Coutifaris C, Sapienza C. Outlier DNA methylation levels as an indicator of environmental exposure and risk of undesirable birth outcome. Hum Mol Genet. 2016 Jan 1;25(1):123-9. doi: 10.1093/hmg/ddv458. Epub 2015 Nov 12. PubMed PMID: 26566672; PubMed Central PMCID: PMC4690496.

Vrooman LA, Xin F, Bartolomei MS. Morphologic and molecular changes in the placenta: what we can learn from environmental exposures. Fertil Steril. 2016 Sep 15;106(4):930-40. doi: 10.1016/j.fertnstert.2016.08.016. Epub 2016 Aug 11. Review. PubMed PMID: 27523298; PubMed Central PMCID: PMC5026950.

Blundell C, Tess ER, Schanzer AS, Coutifaris C, Su EJ, Parry S, Huh D. A microphysiological model of the human placental barrier. Lab Chip. 2016 Aug 2;16(16):3065-73. doi: 10.1039/c6lc00259e. PubMed PMID: 27229450; PubMed Central PMCID: PMC4970951.

Chen M, Jin Y, Penning TM. In-Depth Dissection of the P133R Mutation in Steroid 5β-Reductase (AKR1D1): A Molecular Basis of Bile Acid Deficiency. Biochemistry. 2015 Oct 20;54(41):6343-51. doi: 10.1021/acs.biochem.5b00816. Epub 2015 Oct 6. PubMed PMID: 26418565; PubMed Central PMCID: PMC4696769.

Zhang H, Baldwin DA, Bukowski RK, Parry S, Xu Y, Song C, Andrews WW, Saade GR, Esplin MS, Sadovsky Y, Reddy UM, Ilekis J, Varner M, Biggio JR Jr; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Genomic and Proteomic Network for Preterm Birth Research (GPN-PBR). A genome-wide association study of early spontaneous preterm delivery. Genet Epidemiol. 2015 Mar;39(3):217-26. doi: 10.1002/gepi.21887. Epub 2015 Jan 19. PubMed PMID: 25599974; PubMed Central PMCID: PMC4366311.

Frey HA, Stout MJ, Pearson LN, Tuuli MG, Cahill AG, Strauss JF 3rd, Gomez LM, Parry S, Allsworth JE, Macones GA. Genetic variation associated with preterm birth in African-American women. Am J Obstet Gynecol. 2016 Aug;215(2):235.e1-8. doi: 10.1016/j.ajog.2016.03.008. Epub 2016 Mar 12. PubMed PMID: 26979631; PubMedCentral PMCID: PMC4967390.

Tyrrell J, Richmond RC, Palmer TM, Feenstra B, Rangarajan J, Metrustry S, Cavadino A, Paternoster L, Armstrong LL, De Silva NM, Wood AR, Horikoshi M, Geller F, Myhre R, Bradfield JP, Kreiner-Møller E, Huikari V, Painter JN, Hottenga JJ, Allard C, Berry DJ, Bouchard L, Das S, Evans DM, Hakonarson H, Hayes MG, Heikkinen J, Hofman A, Knight B, Lind PA, McCarthy MI, McMahon G, Medland SE, Melbye M, Morris AP, Nodzenski M, Reichetzeder C, Ring SM, Sebert S, Sengpiel V, Sørensen TI, Willemsen G, de Geus EJ, Martin NG, Spector TD, Power C, Järvelin MR, Bisgaard H, Grant SF, Nohr EA, Jaddoe VW, Jacobsson B, Murray JC, Hocher B, Hattersley AT, Scholtens DM, Davey Smith G, Hivert MF, Felix JF, Hyppönen E, Lowe WL Jr, Frayling TM, Lawlor DA, Freathy RM; Early Growth Genetics (EGG) Consortium. Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. JAMA. 2016 Mar 15;315(11):1129-40. doi: 10.1001/jama.2016.1975. Erratum in: JAMA. 2016 Apr 19;315(15):1661. PubMed PMID: 26978208; PubMed Central PMCID: PMC4811305.

Vrooman LA, Bartolomei MS. Can assisted reproductive technologies cause adult-onset disease? Evidence from human and mouse. Reprod Toxicol. 2016 Jul 26. pii: S0890-6238(16)30302-1. doi: 10.1016/j.reprotox.2016.07.015. [Epub ahead of print] PubMed PMID: 27474254.

Esplin MS, Manuck TA, Varner MW, Christensen B, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J. Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms. Am J Obstet Gynecol. 2015 Sep;213(3):429.e1-9. doi: 10.1016/j.ajog.2015.06.011. Epub 2015 Jun 9. PubMed PMID: 26070700; PubMed Central PMCID: PMC4556543.

Luense LJ, Wang X, Schon SB, Weller AH, Lin Shiao E, Bryant JM, Bartolomei MS, Coutifaris C, Garcia BA, Berger SL. Comprehensive analysis of histone post-translational modifications in mouse and human male germ cells. Epigenetics Chromatin. 2016 Jun 21;9:24. doi: 10.1186/s13072-016-0072-6. eCollection 2016. PubMed PMID: 27330565; PubMed Central PMCID: PMC4915177.

de Waal E, Vrooman LA, Fischer E, Ord T, Mainigi MA, Coutifaris C, Schultz RM, Bartolomei MS. The cumulative effect of assisted reproduction procedures on placental development and epigenetic perturbations in a mouse model. Hum Mol Genet. 2015 Dec 15;24(24):6975-85. doi: 10.1093/hmg/ddv400. Epub 2015 Sep 23. PubMed PMID: 26401051; PubMed Central PMCID: PMC4654053.

Song S, Ghosh J, Mainigi M, Turan N, Weinerman R, Truongcao M, Coutifaris C, Sapienza C. DNA methylation differences between in vitro- and in vivo-conceived children are associated with ART procedures rather than infertility. Clin Epigenetics. 2015 Apr 8;7:41. doi: 10.1186/s13148-015-0071-7. eCollection 2015. PubMed PMID: 25901188; PubMed Central PMCID: PMC4404660.

Xin F, Susiarjo M, Bartolomei MS. Multigenerational and Transgenerational effects of endocrine disrupting chemicals: A role for altered epigenetic regulation? Semin Cell Dev Biol. 2015 Jul;43:66-75. doi: 10.1016/j.semcdb.2015.05.008. Epub 2015 May 28. Review. PubMed PMID: 26026600; PubMed Central PMCID: PMC4662893.

Yohn NL, Bartolomei MS, Blendy JA. Multigenerational and Transgenerational inheritance of drug exposure: The effects of alcohol, opiates, cocaine, marijuana, and nicotine. Prog Biophys Mol Biol. 2015 Jul;118(1-2):21-33. doi:10.1016/j.pbiomolbio.2015.03.002. Epub 2015 Apr 1. Review. PubMed PMID: 25839742; PubMed Central PMCID: PMC4459901.

Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, Bradfield JP, Strachan DP, Li-Gao R, Ahluwalia TS, Kreiner E, Rueedi R, Lyytikäinen LP, Cousminer DL, Wu Y, Thiering E, Wang CA, Have CT, Hottenga JJ, Vilor-Tejedor N, Joshi PK, Boh ETH,  Ntalla I, Pitkänen N, Mahajan A, van Leeuwen EM, Joro R, Lagou V, Nodzenski M, Diver LA, Zondervan KT, Bustamante M, Marques-Vidal P, Mercader JM, Bennett AJ, Rahmioglu N, Nyholt DR, Ma RCW, Tam CHT, Tam WH; CHARGE Consortium Hematology Working Group, Ganesh SK, van Rooij FJ, Jones SE, Loh PR, Ruth KS, Tuke MA, Tyrrell J, Wood AR, Yaghootkar H, Scholtens DM, Paternoster L, Prokopenko I, Kovacs P, Atalay M, Willems SM, Panoutsopoulou K, Wang X, Carstensen L, Geller F, Schraut KE, Murcia M, van Beijsterveldt CE, Willemsen G, Appel EVR, Fonvig CE, Trier C, Tiesler CM, Standl M, Kutalik Z, Bonas-Guarch S, Hougaard DM, Sánchez F, Torrents D, Waage J, Hollegaard MV, de Haan HG, Rosendaal FR, Medina-Gomez C, Ring SM, Hemani G, McMahon G, Robertson NR, Groves CJ, Langenberg C, Luan J, Scott RA, Zhao JH, Mentch FD, MacKenzie SM, Reynolds RM, Lowe WL Jr, Tönjes A, Stumvoll M, Lindi V, Lakka TA, van Duijn CM, Kiess W, Körner A, Sørensen TI, Niinikoski H, Pahkala K, Raitakari OT, Zeggini E, Dedoussis GV, Teo YY, Saw SM, Melbye M, Campbell H, Wilson JF, Vrijheid M, de Geus EJ, Boomsma DI, Kadarmideen HN, Holm JC, Hansen T, Sebert S, Hattersley AT, Beilin LJ, Newnham JP, Pennell CE, Heinrich J, Adair LS, Borja JB, Mohlke KL, Eriksson JG, Widén EE, Kähönen M, Viikari JS, Lehtimäki T, Vollenweider P, Bønnelykke K, Bisgaard H, Mook-Kanamori DO, Hofman A, Rivadeneira F, Uitterlinden AG, Pisinger C, Pedersen O, Power C, Hyppönen E, Wareham NJ, Hakonarson H, Davies E, Walker BR, Jaddoe VW, Jarvelin MR, Grant SF, Vaag AA, Lawlor DA, Frayling TM, Davey Smith G, Morris AP, Ong KK, Felix JF, Timpson NJ, Perry JR, Evans DM, McCarthy MI, Freathy RM. Genome-wide associations for birth weight and correlations with adult disease. Nature. 2016 Oct 13;538(7624):248-252. doi: 10.1038/nature19806. Epub 2016 Sep 28. PubMed PMID: 27680694; PubMed Central PMCID: PMC5164934.

De R, Verma SS, Drenos F, Holzinger ER, Holmes MV, Hall MA, Crosslin DR, Carrell DS, Hakonarson H, Jarvik G, Larson E, Pacheco JA, Rasmussen-Torvik LJ, Moore CB, Asselbergs FW, Moore JH, Ritchie MD, Keating BJ, Gilbert-Diamond D. Identifying gene-gene interactions that are highly associated with Body Mass Index using Quantitative Multifactor Dimensionality Reduction (QMDR). BioData Min. 2015 Dec 14;8:41. doi: 10.1186/s13040-015-0074-0. eCollection 2015. PubMed PMID: 26674805; PubMed Central PMCID: PMC4678717.

Li L, Yin J, Cheng H, Wang Y, Gao S, Li M, Grant SF, Li C, Mi J, Li M. Identification of Genetic and Environmental Factors Predicting Metabolically Healthy Obesity in Children: Data From the BCAMS Study. J Clin Endocrinol Metab. 2016 Apr;101(4):1816-25. doi: 10.1210/jc.2015-3760. Epub 2016 Feb 25. PubMed PMID: 26913634.

Chesi A, Grant SF. The Genetics of Pediatric Obesity. Trends Endocrinol Metab. 2015 Dec;26(12):711-21. doi: 10.1016/j.tem.2015.08.008. Epub 2015 Oct 1. Review. PubMed PMID: 26439977; PubMed Central PMCID: PMC4673034.

CIRCADIAN RHYTHM

Krishnaiah SY, Wu G, Altman BJ, Growe J, Rhoades SD, Coldren F, Venkataraman A, Olarerin-George AO, Francey LJ, Mukherjee S, Girish S, Selby CP, Cal S, Er U, Sianati B, Sengupta A, Anafi RC, Kavakli IH, Sancar A, Baur JA, Dang CV, Hogenesch JB, Weljie AM. Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism. Cell Metab. 2017 Apr 4;25(4):961-974.e4. doi:10.1016/j.cmet.2017.03.019. PubMed PMID: 28380384; PubMed Central PMCID: PMC5479132.

Krishnaiah SY, Wu G, Altman BJ, Growe J, Rhoades SD, Coldren F, Venkataraman A, Olarerin-George AO, Francey LJ, Mukherjee S, Girish S, Selby CP, Cal S, Er U,  Sianati B, Sengupta A, Anafi RC, Kavakli IH, Sancar A, Baur JA, Dang CV, Hogenesch JB, Weljie AM. Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism. Cell Metab. 2017 May 2;25(5):1206. doi:
10.1016/j.cmet.2017.04.023. PubMed PMID: 28467936.

Altman BJ, Hsieh AL, Sengupta A, Krishnanaiah SY, Stine ZE, Walton ZE, Gouw  AM, Venkataraman A, Li B, Goraksha-Hicks P, Diskin SJ, Bellovin DI, Simon MC, Rathmell JC, Lazar MA, Maris JM, Felsher DW, Hogenesch JB, Weljie AM, Dang CV. MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. Cell Metab. 2015 Dec 1;22(6):1009-19. doi: 10.1016/j.cmet.2015.09.003. Epub 2015 Sep 17. PubMed PMID: 26387865; PubMed Central PMCID: PMC4818967.

Yang G, Chen L, Grant GR, Paschos G, Song WL, Musiek ES, Lee V, McLoughlin SC, Grosser T, Cotsarelis G, FitzGerald GA. Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival. Sci Transl Med. 2016 Feb 3;8(324):324ra16. doi: 10.1126/scitranslmed.aad3305. Epub 2016 Feb 3. PubMed PMID: 26843191; PubMed Central PMCID: PMC4870001.

Liang X, Bushman FD, FitzGerald GA. Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10479-84. doi: 10.1073/pnas.1501305112. Epub 2015 Aug 3. PubMed PMID: 26240359; PubMed Central PMCID: PMC4547234.

Sengupta A, Krishnaiah SY, Rhoades S, Growe J, Slaff B, Venkataraman A, Olarerin-George AO, Van Dang C, Hogenesch JB, Weljie AM. Deciphering the Duality  of Clock and Growth Metabolism in a Cell Autonomous System Using NMR Profiling of the Secretome. Metabolites. 2016 Jul 27;6(3). pii: E23. doi: 10.3390/metabo6030023. PubMed PMID: 27472375.

Hsieh P, Woerner AE, Wall JD, Lachance J, Tishkoff SA, Gutenkunst RN, Hammer MF. Model-based analyses of whole-genome data reveal a complex evolutionary history involving archaic introgression in Central African Pygmies. Genome Res. 2016 Mar;26(3):291-300. doi: 10.1101/gr.196634.115. Epub 2016 Feb 17. Erratum in: Genome Res. 2016 May;26(5):717.1. PubMed PMID: 26888264; PubMed Central PMCID: PMC4772012.

Curtis AM, Fagundes CT, Yang G, Palsson-McDermott EM, Wochal P, McGettrick AF, Foley NH, Early JO, Chen L, Zhang H, Xue C, Geiger SS, Hokamp K, Reilly MP, Coogan AN, Vigorito E, FitzGerald GA, O’Neill LA. Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7231-6. doi: 10.1073/pnas.1501327112. Epub 2015 May 20. PubMed PMID: 25995365; PubMed Central PMCID: PMC4466714.

ENVIRONMENTAL EXPOSURES & CANCER

Zhu J, Sammons MA, Donahue G, Dou Z, Vedadi M, Getlik M, Barsyte-Lovejoy D,  Al-awar R, Katona BW, Shilatifard A, Huang J, Hua X, Arrowsmith CH, Berger SL. Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth. Nature. 2015 Sep 10;525(7568):206-11. doi: 10.1038/nature15251. Epub 2015 Sep 2.  PubMed PMID: 26331536; PubMed Central PMCID: PMC4568559.

Shannan B, Watters A, Chen Q, Mollin S, Dörr M, Meggers E, Xu X, Gimotty PA, Perego M, Li L, Benci J, Krepler C, Brafford P, Zhang J, Wei Z, Zhang G, Liu Q, Yin X, Nathanson KL, Herlyn M, Vultur A. PIM kinases as therapeutic targets against advanced melanoma. Oncotarget. 2016 Jul 19. doi: 10.18632/oncotarget.10703. [Epub ahead of print] PubMed PMID: 27448973. 

Wilson MA, Zhao F, Khare S, Roszik J, Woodman SE, D’Andrea K, Wubbenhorst B, Rimm DL, Kirkwood JM, Kluger HM, Schuchter LM, Lee SJ, Flaherty KT, Nathanson KL. Copy Number Changes Are Associated with Response to Treatment with Carboplatin, Paclitaxel, and Sorafenib in Melanoma. Clin Cancer Res. 2016 Jan 15;22(2):374-82. doi: 10.1158/1078-0432.CCR-15-1162. Epub 2015 Aug 25. PubMed PMID: 26307133; PubMed Central PMCID: PMC4821426.

Shannan B, Chen Q, Watters A, Perego M, Krepler C, Thombre R, Li L, Rajan G, Peterson S, Gimotty PA, Wilson M, Nathanson KL, Gangadhar TC, Schuchter LM, Weeraratna AT, Herlyn M, Vultur A. Enhancing the evaluation of PI3K inhibitors through 3D melanoma models. Pigment Cell Melanoma Res. 2016 May;29(3):317-28. doi: 10.1111/pcmr.12465. Epub 2016 Mar 21. PubMed PMID: 26850518; PubMed Central PMCID: PMC4840066.

ENVIRONMENTAL NEUROSCIENCE

DiGuiseppi CG, Daniels JL, Fallin DM, Rosenberg SA, Schieve LA, Thomas KC, Windham GC, Goss CW, Soke GN, Currie DW, Singer AB, Lee LC, Bernal P, Croen LA, Miller LA, Pinto-Martin JA, Young LM, Schendel DE. Demographic profile of families and children in the Study to Explore Early Development (SEED): Case-control study of autism spectrum disorder. Disabil Health J. 2016 Jul;9(3):544-51. doi: 10.1016/j.dhjo.2016.01.005. Epub 2016 Jan 29. PubMed PMID:  26917104; PubMed Central PMCID: PMC4903880.

Mor DE, Ugras SE, Daniels MJ, Ischiropoulos H. Dynamic structural flexibility of α-synuclein. Neurobiol Dis. 2016 Apr;88:66-74. doi: 10.1016/j.nbd.2015.12.018. Epub 2015 Dec 31. Review. PubMed PMID: 26747212; PubMed Central PMCID: PMC4758871.

Worth AJ, Gillespie KP, Mesaros C, Guo L, Basu SS, Snyder NW, Blair IA. Rotenone Stereospecifically Increases (S)-2-Hydroxyglutarate in SH-SY5Y Neuronal Cells. Chem Res Toxicol. 2015 May 18;28(5):948-54. doi: 10.1021/tx500535c. Epub 2015 Apr 8. PubMed PMID: 25800467; PubMed Central PMCID: PMC4721232.

Raju K, Doulias PT, Evans P, Krizman EN, Jackson JG, Horyn O, Daikhin Y, Nissim I, Yudkoff M, Nissim I, Sharp KA, Robinson MB, Ischiropoulos H. Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation. Sci Signal. 2015 Jul 7;8(384):ra68. doi: 10.1126/scisignal.aaa4312. PubMed PMID: 26152695; PubMed Central PMCID: PMC4746709.

Lee JV, Furman R, Axelsen PH. Biosynthesis of uniformly labeled (13)C- and (14)C-arachidonic acid in Mortierella alpina. Bioresour Technol. 2017 Mar;227:142-146. doi: 10.1016/j.biortech.2016.12.050. Epub 2016 Dec 18. PubMed PMID: 28013130; PubMed Central PMCID: PMC5237611.

Axelsen PH, Murphy RC, Igarashi M, Rapoport SI. Increased ω6-Containing Phospholipids and Primary ω6 Oxidation Products in the Brain Tissue of Rats on an ω3-Deficient Diet. PLoS One. 2016 Oct 27;11(10):e0164326. doi: 10.1371/journal.pone.0164326. eCollection 2016. PubMed PMID: 27788153; PubMed Central PMCID: PMC5082804.

Eskici G, Axelsen PH. Amyloid Beta Peptide Folding in Reverse Micelles. J Am Chem Soc. 2017 Jul 19;139(28):9566-9575. doi: 10.1021/jacs.7b03333. Epub 2017 Jul 5. PubMed PMID: 28631483.

Grasso G, Komatsu H, Axelsen PH. Covalent modifications of the amyloid beta peptide by hydroxynonenal: Effects on metal ion binding by monomers and insights into the fibril topology. J Inorg Biochem. 2017 Sep;174:130-136. doi: 10.1016/j.jinorgbio.2017.06.007. Epub 2017 Jun 20. PubMed PMID: 28668508.

Haney CM, Cleveland CL, Wissner RF, Owei L, Robustelli J, Daniels MJ, Canyurt  M, Rodriguez P, Ischiropoulos H, Baumgart T, Petersson EJ. Site-Specific Fluorescence Polarization for Studying the Disaggregation of α-Synuclein Fibrils by Small Molecules. Biochemistry. 2017 Feb 7;56(5):683-691. doi:10.1021/acs.biochem.6b01060. Epub 2016 Nov 11. PubMed PMID: 28045494.

Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, Foroud TM, Friedland RP, Goate AM, Graff-Radford NR, Hendrie H, Hall KS, Hamilton-Nelson KL, Inzelberg R, Kamboh MI, Kauwe JSK, Kukull WA, Kunkle BW, Kuwano R, Larson EB, Logue MW, Manly JJ, Martin ER, Montine TJ, Mukherjee S, Naj A, Reiman EM, Reitz C, Sherva R, St George-Hyslop PH, Thornton T, Younkin SG, Vardarajan BN, Wang LS, Wendlund JR, Winslow AR; Alzheimer’s Disease Genetics Consortium, Haines J, Mayeux R, Pericak-Vance MA, Schellenberg G, Lunetta KL, Farrer LA. Transethnic genome-wide scan identifies novel Alzheimer’s disease loci. Alzheimers Dement. 2017 Jul;13(7):727-738. doi: 10.1016/j.jalz.2016.12.012. Epub 2017 Feb 7. PubMed PMID: 28183528; PubMed Central PMCID: PMC5496797.

Weiner DJ, Wigdor EM, Ripke S, Walters RK, Kosmicki JA, Grove J, Samocha KE, Goldstein JI, Okbay A, Bybjerg-Grauholm J, Werge T, Hougaard DM, Taylor J; iPSYCH-Broad Autism Group; Psychiatric Genomics Consortium Autism Group, Skuse D, Devlin B, Anney R, Sanders SJ, Bishop S, Mortensen PB, Børglum AD, Smith GD, Daly MJ, Robinson EB. Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders. Nat Genet. 2017 Jul;49(7):978-985. doi: 10.1038/ng.3863. Epub 2017 May 15. PubMed PMID: 28504703.

Geisheker MR, Heymann G, Wang T, Coe BP, Turner TN, Stessman HAF, Hoekzema K, Kvarnung M, Shaw M, Friend K, Liebelt J, Barnett C, Thompson EM, Haan E, Guo H, Anderlid BM, Nordgren A, Lindstrand A, Vandeweyer G, Alberti A, Avola E, Vinci M, Giusto S, Pramparo T, Pierce K, Nalabolu S, Michaelson JJ, Sedlacek Z, Santen GWE, Peeters H, Hakonarson H, Courchesne E, Romano C, Kooy RF, Bernier RA, Nordenskjöld M, Gecz J, Xia K, Zweifel LS, Eichler EE. Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains. Nat Neurosci. 2017 Jun 19. doi: 10.1038/nn.4589. [Epub ahead of print] PubMed PMID: 28628100.

AIR POLUTION & LUNG HEALTH

Anderson WC 3rd, Apter A, Dutmer CM, Searing DA, Szefler SJ. Advances in Asthma 2016: Designing Individualized Approaches to Management. J Allergy Clin Immunol. 2017 Jul 11. pii: S0091-6749(17)31093-X. doi:10.1016/j.jaci.2017.06.015. [Epub ahead of print] PubMed PMID: 28709967.

Korwin A, Black H, Perez L, Morales KH, Klusaritz H, Han X, Huang J, Rogers M, Ndicu G, Apter AJ. Exploring Patient Engagement: A Qualitative Analysis of Low-Income Urban Participants in Asthma Research. J Allergy Clin Immunol Pract. 2017 May 10. pii: S2213-2198(17)30193-9. doi: 10.1016/j.jaip.2017.03.022. [Epub ahead of print] PubMed PMID: 28499772.

Apter AJ, Morales KH, Han X, Perez L, Huang J, Ndicu G, Localio A, Nardi A, Klusaritz H, Rogers M, Phillips A, Cidav Z, Schwartz JS. A patient advocate to facilitate access and improve communication, care, and outcomes in adults with moderate or severe asthma: Rationale, design, and methods of a randomized controlled trial. Contemp Clin Trials. 2017 May;56:34-45. doi: 10.1016/j.cct.2017.03.004. Epub 2017 Mar 14. PubMed PMID: 28315481; PubMed Central PMCID: PMC5503302.

Kramer CB, LeRoy L, Donahue S, Apter AJ, Bryant-Stephens T, Elder JP, Hamilton WJ, Krishnan JA, Shelef DQ, Stout JW, Sumino K, Teach SJ, Federman AD. Enrolling  African-American and Latino patients with asthma in comparative effectiveness research: Lessons learned from 8 patient-centered studies. J Allergy Clin Immunol. 2016 Dec;138(6):1600-1607. doi: 10.1016/j.jaci.2016.10.011. Epub 2016 Oct 24. PubMed PMID: 27789250.

Bryant-Stephens T, Reed-Wells S, Canales M, Perez L, Rogers M, Localio AR, Apter AJ. Home visits are needed to address asthma health disparities in adults.  J Allergy Clin Immunol. 2016 Dec;138(6):1526-1530. doi: 10.1016/j.jaci.2016.10.006. Epub 2016 Oct 21. Review. PubMed PMID: 27777181.

Perez L, Morales KH, Klusaritz H, Han X, Huang J, Rogers M, Bennett IM, Rand CS, Ndicu G, Apter AJ. A health care navigation tool assesses asthma self-management and health literacy. J Allergy Clin Immunol. 2016 Dec;138(6):1593-1599.e3. doi: 10.1016/j.jaci.2016.08.043. Epub 2016 Oct 13. PubMed PMID: 27744030; PubMed Central PMCID: PMC5148700.

Krishnaiah SY, Dodia C, Sorokina EM, Li H, Feinstein SI, Fisher AB. Binding sites for interaction of peroxiredoxin 6 with surfactant protein A. Biochim Biophys Acta. 2016 Apr;1864(4):419-25. doi: 10.1016/j.bbapap.2015.12.009. Epub 2015 Dec 23. PubMed PMID: 26723227; PubMed Central PMCID: PMC4763979.

Kook S, Wang P, Young LR, Schwake M, Saftig P, Weng X, Meng Y, Neculai D, Marks MS, Gonzales L, Beers MF, Guttentag S. Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 Delivery to Lamellar Bodies Accounts for Altered Alveolar Phospholipid Content in Adaptor Protein-3-deficient pearl Mice. J Biol Chem. 2016 Apr 15;291(16):8414-27. doi: 10.1074/jbc.M116.720201. Epub 2016 Feb 23. PubMed PMID: 26907692; PubMed Central PMCID: PMC4861416.

Gould NS, Evans P, Martínez-Acedo P, Marino SM, Gladyshev VN, Carroll KS, Ischiropoulos H. Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks. Chem Biol. 2015 Jul 23;22(7):965-75. doi: 10.1016/j.chembiol.2015.06.010. Epub 2015 Jul 9. PubMed PMID: 26165157; PubMed Central PMCID: PMC4515171.

Vázquez-Medina JP, Dodia C, Weng L, Mesaros C, Blair IA, Feinstein SI, Chatterjee S, Fisher AB. The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonary endothelium and alveolar macrophages. FASEB J. 2016 Aug;30(8):2885-98. doi: 10.1096/fj.201500146R. Epub 2016 May 13. PubMed PMID: 27178323; PubMed Central PMCID: PMC4970605.

Erickson MA, Jude J, Zhao H, Rhea EM, Salameh TS, Jester W, Pu S, Harrowitz J, Nguyen N, Banks WA, Panettieri RA Jr, Jordan-Sciutto KL. Serum amyloid A: an ozone-induced circulating factor with potentially important functions in the lung-brain axis. FASEB J. 2017 May 22. pii: fj.201600857RRR. doi:10.1096/fj.201600857RRR. [Epub ahead of print] PubMed PMID: 28533327.

Wackowski OA, Hammond D, O’Connor RJ, Strasser AA, Delnevo CD. Considerations and Future Research Directions for E-Cigarette Warnings-Findings from Expert Interviews. Int J Environ Res Public Health. 2017 Jul 14;14(7). pii: E781. doi: 10.3390/ijerph14070781. PubMed PMID: 28708124.

Paris AJ, Liu Y, Mei J, Dai N, Guo L, Spruce LA, Hudock KM, Brenner JS, Zacharias WJ, Mei HD, Slamowitz AR, Bhamidipati K, Beers MF, Seeholzer SH, Morrisey EE, Worthen GS. Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1062-L1075. doi:10.1152/ajplung.00327.2016. Epub 2016 Sep 30. PubMed PMID: 27694472; PubMed Central PMCID: PMC5206401.

Beers MF, Moodley Y. When Is an Alveolar Type 2 Cell an Alveolar Type 2 Cell?  A Conundrum for Lung Stem Cell Biology and Regenerative Medicine. Am J Respir Cell Mol Biol. 2017 Jul;57(1):18-27. doi: 10.1165/rcmb.2016-0426PS. Review. PubMed PMID: 28326803; PubMed Central PMCID: PMC5516281.

Beers MF, Knudsen L, Tomer Y, Maronn J, Zhao M, Ochs M, Mulugeta S. Aberrant lung remodeling in a mouse model of surfactant dysregulation induced by modulation of the Abca3 gene. Ann Anat. 2017 Mar;210:135-146. doi:10.1016/j.aanat.2016.11.015. Epub 2016 Dec 26. PubMed PMID: 28034695.

Beers MF, Mulugeta S. The biology of the ABCA3 lipid transporter in lung health and disease. Cell Tissue Res. 2017 Mar;367(3):481-493. 10.1007/s00441-016-2554-z. Epub 2016 Dec 26. Review. PubMed PMID: 28025703;PubMed Central PMCID: PMC5321817.

Hersh CP, Vachani A. Whole-Genome Sequencing in Common Respiratory Diseases. Ready, Set, Go! Am J Respir Crit Care Med. 2017 Jul 15;196(2):121-122. doi: 10.1164/rccm.201703-0479ED. PubMed PMID: 28707973.

ASTHMA

Bushong A, McKeon T, Regina Boland M, Field J. Publicly available data reveals association between asthma hospitalizations and unconventional natural gas development in Pennsylvania. PLoS One. 2022;17(3):e0265513. Published 2022 Mar 31. doi:10.1371/journal.pone.0265513; PubMed Central PMCID: PMC8970380. 

Koziol-White CJ, Jia Y, Baltus GA, Cooper PR, Zaller DM, Crackower MA, Sirkowski EE, Smock S, Northrup AB, Himes BE, Alves SE, Panettieri RA Jr. Inhibition of spleen tyrosine kinase attenuates IgE-mediated airway contraction and mediator release in human precision cut lung slices. Br J Pharmacol. 2016 Nov;173(21):3080-3087. doi: 10.1111/bph.13550. Epub 2016 Oct 5. PubMed PMID: 27417329; PubMed Central PMCID: PMC5056227.

Greenblatt R, Mansour O, Zhao E, Ross M, Himes BE. Gender-specific determinants of asthma among U.S. adults. Asthma Res Pract. 2017 Jan 24;3:2. doi: 10.1186/s40733-017-0030-5. eCollection 2017. PubMed PMID: 28138394; PubMed Central PMCID: PMC5259982.

Himes BE, Ortega VE. Making progress toward understanding the genetic architecture of asthma in the most affected US ethnic group. Eur Respir J. 2017 May 1;49(5). pii: 1700329. doi: 10.1183/13993003.00329-2017. Print 2017 May. PubMed PMID: 28461304.

Hysinger EB, Roizen JD, Mentch FD, Vazquez L, Connolly JJ, Bradfield JP, Almoguera B, Sleiman PM, Allen JL, Levine MA, Hakonarson H. Mendelian randomization analysis demonstrates that low vitamin D is unlikely causative for pediatric asthma. J Allergy Clin Immunol. 2016 Dec;138(6):1747-1749.e4. doi: 10.1016/j.jaci.2016.06.056. Epub 2016 Aug 20. PubMed PMID: 27554823.

Almoguera B, Vazquez L, Mentch F, Connolly J, Pacheco JA, Sundaresan AS, Peissig PL, Linneman JG, McCarty CA, Crosslin D, Carrell DS, Lingren T, Namjou-Khales B, Harley JB, Larson E, Jarvik GP, Brilliant M, Williams MS, Kullo IJ, Hysinger EB, Sleiman PM, Hakonarson H. Identification of Four Novel Loci in Asthma in European American and African American Populations. Am J Respir Crit Care Med. 2017 Feb 15;195(4):456-463. doi: 10.1164/rccm.201604-0861OC. PubMed PMID: 27611488; PubMed Central PMCID: PMC5378422.

Wu AC, Carpenter JF, Himes BE. Mobile health applications for asthma. J Allergy Clin Immunol Pract. 2015 May-Jun;3(3):446-8.e1-16. doi:10.1016/j.jaip.2014.12.011. Epub 2015 Feb 25. Review. PubMed PMID: 25725939.

Koziol-White CJ, Yoo EJ, Cao G, Zhang J, Papanikolaou E, Pushkarsky I, Andrews A, Himes BE, Damoiseaux RD, Liggett SB, Di Carlo D, Kurten RC, Panettieri RA Jr. Inhibition of PI3K promotes dilation of human small airways in a rho kinase-dependent manner. Br J Pharmacol. 2016 Jun 28. doi: 10.1111/bph.13542. [Epub ahead of print] PubMed PMID: 27352269.

Koziol-White CJ, Jia Y, Baltus GA, Cooper PR, Zaller DM, Crackower MA, Sirkowski EE, Smock S, Northrup AB, Himes BE, Alves SE, Panettieri RA Jr. Inhibition of spleen tyrosine kinase attenuates IgE-mediated airway contraction and mediator release in human precision cut lung slices. Br J Pharmacol. 2016 Jul 15. doi: 10.1111/bph.13550. [Epub ahead of print] PubMed PMID: 27417329.

COPD
Castaldi PJ, Vachani A. Recognizing the Many Faces of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 Jun 1;193(11):1190-2. doi: 10.1164/rccm.201601-0125ED. PubMed PMID: 27248584; PubMed Central PMCID: PMC4910904.

Hersh CP, Vachani A. Whole-Genome Sequencing in Common Respiratory Diseases. Ready, Set, Go! Am J Respir Crit Care Med. 2017 Jul 15;196(2):121-122. doi: 10.1164/rccm.201703-0479ED. PubMed PMID: 28707973.

ENVIRONMENTAL EXPOSURE & LUNG HEALTH

Shestov AA, Lee SC, Nath K, Guo L, Nelson DS, Roman JC, Leeper DB, Wasik MA, Blair IA, Glickson JD. (13)C MRS and LC-MS Flux Analysis of Tumor Intermediary Metabolism. Front Oncol. 2016 Jun 15;6:135. doi: 10.3389/fonc.2016.00135.eCollection 2016. PubMed PMID: 27379200; PubMed Central PMCID: PMC4908130.

McConnell YJ, Farshidfar F, Weljie AM, Kopciuk KA, Dixon E, Ball CG, Sutherland FR, Vogel HJ, Bathe OF. Distinguishing Benign from Malignant Pancreatic and Periampullary Lesions Using Combined Use of ¹H-NMR Spectroscopy and Gas Chromatography-Mass Spectrometry. Metabolites. 2017 Jan 13;7(1). pii: E3. doi: 10.3390/metabo7010003. PubMed PMID: 28098776; PubMed Central PMCID:PMC5372206.

Snyder NW, Mesaros C, Blair IA. Translational metabolomics in cancer research. Biomark Med. 2015;9(9):821-34. doi: 10.2217/bmm.15.52. Epub 2015 Sep 1. Review. PubMed PMID: 26329905; PubMed Central PMCID: PMC4718447.

Hao D, Sarfaraz MO, Farshidfar F, Bebb DG, Lee CY, Card CM, David M, Welji A. Temporal characterization of serum metabolite signatures in lung cancer patients undergoing treatment. Metabolomics. 2016;12:58. Epub 2016 Feb 27. PubMed PMID: 27073350; PubMed Central PMCID: PMC4819600.

Shestov AA, Lee SC, Nath K, Guo L, Nelson DS, Roman JC, Leeper DB, Wasik MA, Blair IA, Glickson JD. (13)C MRS and LC-MS Flux Analysis of Tumor Intermediary Metabolism. Front Oncol. 2016 Jun 15;6:135. doi: 10.3389/fonc.2016.00135. eCollection 2016. PubMed PMID: 27379200; PubMed Central PMCID: PMC4908130.

Shestov AA, Mancuso A, Lee SC, Guo L, Nelson DS, Roman JC, Henry PG, Leeper DB, Blair IA, Glickson JD. Bonded Cumomer Analysis of Human Melanoma Metabolism Monitored by 13C NMR Spectroscopy of Perfused Tumor Cells. J Biol Chem. 2016 Mar 4;291(10):5157-71. doi: 10.1074/jbc.M115.701862. Epub 2015 Dec 24. PubMed PMID: 26703469; PubMed Central PMCID: PMC4777850.

Kawalekar OU, O’Connor RS, Fraietta JA, Guo L, McGettigan SE, Posey AD Jr, Patel PR, Guedan S, Scholler J, Keith B, Snyder NW, Blair IA, Milone MC, June CH. Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells. Immunity. 2016 Feb 16;44(2):380-90. doi: 10.1016/j.immuni.2016.01.021. Erratum in: Immunity. 2016 Mar 15;44(3):712. Snyder, Nathaniel [corrected to Snyder, Nathaniel W]; Blair, Ian [corrected to Blair, Ian A]. PubMed PMID: 26885860

METABOLOMICS

Worth AJ, Marchione DM, Parry RC, Wang Q, Gillespie KP, Saillant NN, Sims C, Mesaros C, Snyder NW, Blair IA. LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism. J Vis Exp. 2016 Apr 4;(110):e53941. doi: 10.3791/53941. PubMed PMID: 27077278; PubMed Central PMCID: PMC4841355.

Rhoades SD, Weljie AM. Comprehensive Optimization of LC-MS Metabolomics Methods Using Design of Experiments (COLMeD). Metabolomics. 2016 Dec;12(12). pii:doi: 10.1007/s11306-016-1132-4. Epub 2016 Oct 24. PubMed PMID: 28348510; PubMed Central PMCID: PMC5364801.

Guo L, Worth AJ, Mesaros C, Snyder NW, Glickson JD, Blair IA. Diisopropylethylamine/hexafluoroisopropanol-mediated ion-pairing ultra-high-performance liquid chromatography/mass spectrometry for phosphate and carboxylate metabolite analysis: utility for studying cellular metabolism. Rapid Commun Mass Spectrom. 2016 Aug 30;30(16):1835-45. doi: 10.1002/rcm.7667. PubMed PMID: 27476658; PubMed Central PMCID: PMC4970762.

COMMUNITY ENGAGEMENT

O’Shea MJ, Toupal J, Caballero-Gómez H, McKeon TP, Howarth MV, Pepino R, Gieré R. Lead Pollution, Demographics, and Environmental Health Risks: The Case of Philadelphia, USA. Int J Environ Res Public Health. 2021 Aug 27;18(17):9055. doi: 10.3390/ijerph18179055. PMID: 34501644; PMCID: PMC8431549.

Caballero-Gómez H, White HK, O’Shea MJ, Pepino R, Howarth M, Gieré R. Spatial Analysis and Lead-Risk Assessment of Philadelphia, USA. Geohealth. 2022 Mar 1;6(3):e2021GH000519. doi: 10.1029/2021GH000519. PMID: 35340281; PMCID: PMC8934574.

Castle M, Cleveland C, Gordon D, Jones L, Zelinski M, Winter P, Chang J, Senegar-Mitchell E, Coutifaris C, Shuda J, Mainigi M, Bartolomei M, Woodruff TK.  Reproductive Science for High School Students: A Shared Curriculum Model toEnhance Student Success. Biol Reprod. 2016 Jul;95(1):28. doi: 10.1095/biolreprod.116.139998. Epub 2016 Jun 22. PubMed PMID: 27335072.

Cossette C, Gravel S, Reddy CN, Gore V, Chourey S, Ye Q, Snyder NW, Mesaros CA, Blair IA, Lavoie JP, Reinero CR, Rokach J, Powell WS. Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes. Biochem Pharmacol. 2015 Aug 1;96(3):247-55. doi: 10.1016/j.bcp.2015.05.009. Epub 2015 May 29. PubMed PMID: 26032638; PubMed Central PMCID: PMC4830392.

Mazzulli JR, Burbulla LF, Krainc D, Ischiropoulos H. Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence. Anal Chem. 2016 Feb 16;88(4):2399-405. doi: 10.1021/acs.analchem.5b04420. Epub 2016 Feb 3. PubMed PMID: 26813311.

PUBLIC HEALTH

Ji X, Liu J. Associations between Blood Zinc Concentrations and Sleep Quality in Childhood: A Cohort Study. Nutrients. 2015 Jul 13;7(7):5684-96. doi: 10.3390/nu7075247. PubMed PMID: 26184300; PubMed Central PMCID: PMC4517024.

Bleakley A, Jordan AB, Hennessy M, Glanz K, Strasser A, Vaala S. Do Emotional Appeals in Public Service Advertisements Influence Adolescents’ Intention to Reduce Consumption of Sugar-Sweetened Beverages? J Health Commun.2015 Aug;20(8):938-48. doi: 10.1080/10810730.2015.1018593. Epub 2015 Jun 9. PubMed PMID: 26054656.

 Zhou G, Ji X, Cui N, Cao S, Liu C, Liu J. Association between Serum Copper Status and Working Memory in Schoolchildren. Nutrients. 2015 Aug 27;7(9):7185-96. doi: 10.3390/nu7095331. PubMed PMID: 26343713; PubMed Central PMCID: PMC4586526.

Souders MC, Zavodny S, Eriksen W, Sinko R, Connell J, Kerns C, Schaaf R, Pinto-Martin J. Sleep in Children with Autism Spectrum Disorder. Curr Psychiatry  Rep. 2017 Jun;19(6):34. doi: 10.1007/s11920-017-0782-x. Review. PubMed PMID: 28502070.

Ji X, Cui N, Liu J. Neurocognitive Function Is Associated With Serum Iron Status in Early Adolescents. Biol Res Nurs. 2017 May;19(3):269-277. doi: 10.1177/1099800417690828. Epub 2017 Feb 15. PubMed PMID: 28196427.

Shi Z, Zhen S, Orsini N, Zhou Y, Zhou Y, Liu J, Taylor AW. Association between dietary lead intake and 10-year mortality among Chinese adults. Environ Sci Pollut Res Int. 2017 May;24(13):12273-12280. doi: 10.1007/s11356-017-8871-2. Epub 2017 Mar 29. PubMed PMID: 28357790.

Strasser AA, Souprountchouk V, Kaufmann A, Blazekovic S, Leone F, Benowitz NL, Schnoll RA. Nicotine Replacement, Topography, and Smoking Phenotypes of E-cigarettes. Tob Regul Sci. 2016 Oct;2(4):352-362. PubMed PMID: 27942543; PubMed Central PMCID: PMC5142626.

Mercincavage M, Wileyto EP, Saddleson ML, Lochbuehler K, Donny EC, Strasser AA. Attrition during a randomized controlled trial of reduced nicotine content cigarettes as a proxy for understanding acceptability of nicotine product standards. Addiction. 2017 Jun;112(6):1095-1103. doi: 10.1111/add.13766. Epub 2017 Feb 23. PubMed PMID: 28107596; PubMed Central PMCID: PMC5407938.

Romer D, Ferguson SG, Strasser AA, Evans AT, Tompkins MK, Macisco J, Fardal M, Tusler M, Peters E. Effects of Pictorial Warning Labels for Cigarettes and Quit-Efficacy on Emotional Responses, Smoking Satisfaction, and Cigarette Consumption. Ann Behav Med. 2017 May 9. doi: 10.1007/s12160-017-9916-y. [Epub ahead of print] PubMed PMID: 28488230.

Mercincavage M, Saddleson ML, Gup E, Halstead A, Mays D, Strasser AA. Reduced nicotine content cigarette advertising: How false beliefs and subjective ratings affect smoking behavior. Drug Alcohol Depend. 2017 Apr 1;173:99-106. doi: 10.1016/j.drugalcdep.2016.12.022. Epub 2017 Feb 3. PubMed PMID: 28214392; PubMed Central PMCID: PMC5366263.

Lochbuehler K, Mercincavage M, Tang KZ, Dana Tomlin C, Cappella JN, Strasser. Effect of message congruency on attention and recall in pictorial health warning labels. Tob Control. 2017 May 16. pii: tobaccocontrol-2016-053615. doi: 10.1136/tobaccocontrol-2016-053615. [Epub ahead of print] PubMed PMID: 28512171.

Kraemer JD, Strasser AA, Lindblom EN, Niaura RS, Mays D. Crowdsourced data collection for public health: A comparison with nationally representative, population tobacco use data. Prev Med. 2017 Jul 8;102:93-99. doi:10.1016/j.ypmed.2017.07.006. [Epub ahead of print] PubMed PMID: 28694063.

Su J, Cui N, Zhou G, Ai Y, Sun G, Zhao SR, Liu J. Hemoglobin Status and Externalizing Behavioral Problems in Children. Int J Environ Res Public Health. 2016 Jul 26;13(8). pii: E758. doi: 10.3390/ijerph13080758. PubMed PMID: 27472352.

Lochbuehler K, Tang KZ, Souprountchouk V, Campetti D, Cappella JN, Kozlowski LT, Strasser AA. Using eye-tracking to examine how embedding risk corrective statements improves cigarette risk beliefs: Implications for tobacco regulatory policy. Drug Alcohol Depend. 2016 Jul 1;164:97-105. doi: 10.1016/j.drugalcdep.2016.04.031. Epub 2016 May 2. PubMed PMID: 27160034; PubMed Central PMCID: PMC4893893.

Tsaur S, Strasser AA, Souprountchouk V, Evans GC, Ashare RL. Time dependency of craving and response inhibition during nicotine abstinence. Addict Res Theory. 2015;23(3):205-212. PubMed PMID: 26052265; PubMed Central PMCID: PMC4456025.

Wackowski OA, O’Connor RJ, Strasser AA, Hammond D, Villanti AC, Delnevo CD. Smokers’ and e-cigarette users’ perceptions of modified risk warnings for e-cigarettes. Prev Med Rep. 2016 Jul 10;4:309-12. doi: 10.1016/j.pmedr.2016.07.005. eCollection 2016 Dec. PubMed PMID: 27486560; PubMed Central PMCID: PMC4960008.

Wackowski OA, Hammond D, O’Connor RJ, Strasser AA, Delnevo CD. Smokers’ and E-Cigarette Users’ Perceptions about E-Cigarette Warning Statements. Int J Environ Res Public Health. 2016 Jun 30;13(7). pii: E655. doi: 10.3390/ijerph13070655. PubMed PMID: 27376310; PubMed Central PMCID: PMC4962196.

Audrain-McGovern J, Strasser AA, Ashare R, Wileyto EP. Reinforcing value of smoking relative to physical activity and the effects of physical activity on smoking abstinence symptoms among young adults. Exp Clin Psychopharmacol. 2015 Dec;23(6):477-85. doi: 10.1037/pha0000051. Epub 2015 Sep 7. PubMed PMID: 26348158; PubMed Central PMCID: PMC4658299.

Donny EC, Denlinger RL, Tidey JW, Koopmeiners JS, Benowitz NL, Vandrey RG, al’Absi M, Carmella SG, Cinciripini PM, Dermody SS, Drobes DJ, Hecht SS, Jensen J, Lane T, Le CT, McClernon FJ, Montoya ID, Murphy SE, Robinson JD, Stitzer ML, Strasser AA, Tindle H, Hatsukami DK. Randomized Trial of Reduced-Nicotine Standards for Cigarettes. N Engl J Med. 2015 Oct;373(14):1340-9. doi: 10.1056/NEJMsa1502403. PubMed PMID: 26422724; PubMed Central PMCID: PMC4642683.

Mercincavage M, Souprountchouk V, Tang KZ, Dumont RL, Wileyto EP, Carmella SG, Hecht SS, Strasser AA. A Randomized Controlled Trial of Progressively Reduced Nicotine Content Cigarettes on Smoking Behaviors, Biomarkers of Exposure, and Subjective Ratings. Cancer Epidemiol Biomarkers Prev. 2016 Jul;25(7):1125-33. doi: 10.1158/1055-9965.EPI-15-1088. Epub 2016 Apr 27. PubMed PMID: 27197288; PubMed Central PMCID: PMC4930705.

Reilly JP, Christie JD. Primed for Injury: Cigarette Smokers and Acute Respiratory Distress Syndrome. Crit Care Med. 2015 Sep;43(9):2015-6. doi: 10.1097/CCM.0000000000001121. PubMed PMID: 26274703; PubMed Central PMCID: PMC4538990.

Mitchell JA, Chesi A, Elci O, McCormack SE, Roy SM, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Grant SF, Zemel BS. Physical Activity Benefits the Skeleton of Children Genetically Predisposed to Lower Bone Density in Adulthood. J Bone Miner Res. 2016 Aug;31(8):1504-12. doi: 10.1002/jbmr.2872. PubMed PMID: 27172274; PubMed Central PMCID: PMC4970901.

Raine A, Cheney RA, Ho R, Portnoy J, Liu J, Soyfer L, Hibbeln J, Richmond A. Nutritional supplementation to reduce child aggression: a randomized, stratified, single-blind, factorial trial. J Child Psychol Psychiatry. 2016 May 11 doi: 10.1111/jcpp.12565. [Epub ahead of print] PubMed PMID: 27166583.

Liu J, Raine A. Nutritional status and social behavior in preschool children: the mediating effects of neurocognitive functioning. Matern Child Nutr. 2016 May 1. doi: 10.1111/mcn.12321. [Epub ahead of print] PubMed PMID: 27133006.

Shenderovich Y, Eisner M, Mikton C, Gardner F, Liu J, Murray J. Methods for conducting systematic reviews of risk factors in low- and middle-income countries. BMC Med Res Methodol. 2016 Mar 15;16:32. doi: 10.1186/s12874-016-0134-2. PubMed PMID: 26979282; PubMed Central PMCID: PMC4791911.

Himes BE, Weitzman ER. Innovations in health information technologies for chronic pulmonary diseases. Respir Res. 2016 Apr 5;17:38. doi: 10.1186/s12931-016-0354-3. Review. PubMed PMID: 27048618; PubMed Central PMCID:PMC4822326.

Evans AT, Peters E, Strasser AA, Emery LF, Sheerin KM, Romer D. Graphic Warning Labels Elicit Affective and Thoughtful Responses from Smokers: Results of a Randomized Clinical Trial. PLoS One. 2015 Dec 16;10(12):e0142879. doi: 10.1371/journal.pone.0142879. eCollection 2015. PubMed PMID: 26672982; PubMed Central PMCID: PMC4684406.

Zinkel SR, Berkowitz RI, Stunkard AJ, Stallings VA, Faith M, Thomas D, Schoeller DA. High energy expenditure is not protective against increased adiposity in children. Pediatr Obes. 2016 Feb 22. doi: 10.1111/ijpo.12099. [Epub ahead of print] PubMed PMID: 26909758.

Audrain-McGovern J, Strasser AA, Wileyto EP. The impact of flavoring on the rewarding and reinforcing value of e-cigarettes with nicotine among young adult smokers. Drug Alcohol Depend. 2016 Sep 1;166:263-7. doi: 10.1016/j.drugalcdep.2016.06.030. Epub 2016 Jul 1. PubMed PMID: 27426010.