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Environmental Exposures and Cancer (EC)

The EC thematic area elucidates the link  between exposures to carcinogens, e.g. asbestos, air pollution (e.g. PAH and NO2-PAH), environmental tobacco smoke (ETS) and UV light to their adverse outcomes to identify individuals most at risk using biomarkers of exposure and effect. The Thematic Area is led by Ian A. Blair, PhD (AN Richards Professor of Pharmacology). The EC team has expertise in exposure assessment, mechanistic carcinogenesis, thoracic and skin malignancies, and community engagement. The EC team conducts community engaged research in Ambler PA, the site of the Bo-RiT Asbestos Superfund Site. It advises the Community Engagement Core and the Eastwick Lower Darby Creek Area (ELDCA) Community Advisory Group (CAG) on PAH contamination of residential yards from leachate from the Clearview Landfill Superfund site. Several of the EC investigators also belong to the Tobacco and Environmental Chemical Carcinogenesis Program of the Abramson Cancer Center.

Environmental Exposures and Cancer

Steve Albelda, MD

Research Interest: Carcinogen Exposure and Lung Cancer and Mesothelioma

Frances Barg, PhD

Research Interest: Mixed Methods Approach with Focus on the Uneven Distribution of Risk and Disease among Ethnic Groups

Ian Blair, PhD (Leader)

Research Interest: Oxidative Stress, Biomarkers of Human Disease

Eric Brown, PhD

Research Interest: Repair and Replication Fork Collapse

Brian C. Capell, MD, PhD

Research Interest: Epigenetic and Epitranscriptomic Mechanisms

Melpo Christofidou-Solomidou, PhD

Research Interest: Animal Models of Lung Disease and Chemoprevention with Anti-oxidants

David Feldser, PhD

Research Interest: Physiological Role of p53, Rb, and Kras in Lung Cancer

Jeffrey Field, PhD

Research Interest: Reactive Oxygen Species Mutagenesis of p53

Aime T. Franco, PhD

Research Interest: Dissecting the Molecular and Cellular Differences of Pediatric and Adult Cancer

Reto Gieré, PhD

Research Interest: Health Effects of Atmospheric Particles

Marilyn Howarth, MD

Research Interest: Community Engagement

Wei-Ting Hwang, PhD

Research Interest:  Cluster Analysis

Douglas Jerolmack, PhD

Research Interest: Transport of Particles in the Environment by Water and Wind

Marcelo Kazanietz, PhD

Research Interest: Signal Transduction Mechanisms in Cancer

Despina Kontos, PhD

Research Interest: Environmental Exposures of COPD and Lung Cancer

Maayan Levy, PhD

Research Interest: Interaction between the Intestinal Microbiome, Environmental Xenobiotics and Colorectal Cancer

Clementina Mesaros, PhD

Research Interest: Assays for Metabolites Involved in Cellular Oxidative Stress

Trevor Penning, PhD

Research Interest: Human-Aldo Reductase (AKR) Genes in Hormonal and Chemical Carcinogenesis

Ileana  Perez-Rodriguez, PhD

Research Interest: Microbial Growth Relevant to Chemosynthetic Metabolisms.

John Seykora, MD, PhD

Research Interest: How UV-irradiation Promotes Skin Cancer

Andrew Strasser, PhD

Research Interest: Smoking Behavior, Nicotine Addiction and Low Dose Nicotine Cigarettes

Sarah Tishkoff, PhD

Research Interest: African Genetic Diversity

Anil Vachani, MD, MSCE

Research Interest: Genetic Susceptibility and Biomarkers of Lung Cancer and Mesothelioma


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