The Center of Excellence in Environmental Toxicology announces the following pilot project opportunity. Applications are due Friday, January 19, 2018. (note change in deadline)
Focus Research Awards:
Applications related to the following areas are currently being accepted:
- Air Pollution and Particulates e.g. polycyclic aromatic hydrocarbons, diesel exhaust, priority air-pollutants, environmental tobacco smoke, vaping from E-cigarettes, asbestos, nanoparticles, road dust etc.
- Windows of Susceptibility e.g. exposures to any toxicant during vulnerable periods of the life span (in utero, pre- and post-natal, pre-puberty, and the elderly).Applications in either area should contain one or more of the following components: exposure assessment; adverse outcome to the exposure; or translation of research findings to communities or patient prevention, intervention and treatment.
Applicants can request up to $50,000 for one year. No salary support for the faculty member is allowable. Any member of the standing or research faculty from any School may apply.
Other Eligibility Requirements:
The research being proposed cannot be funded by an external funding agency. Preference will be given to first-time applicants and senior faculty who wish to embrace environmental health or toxicology research as a new direction. Applications that are likely to lead to grant funding from the National Institute of Environmental Health Sciences (NIEHS) and use the facility cores of the CEET (Integrative Health Sciences Facility Core, Translational Biomarker Core or the Exposure Biology Informatics Core) are actively encouraged. To learn more about the facility cores please visit the CEET web-site.
If funded, a progress report is required within 3 months of the end of the funding period. The progress report should follow the same format as that required for an NIH R01 RPPR-progress report. Awardees must present their findings at a CEET Seminar within 6 months of the end of the funding cycle. The CEET must be acknowledged on all publications resulting from the supported research.
All IRB and IACUC protocols must be in place before the funding can be awarded. A copy of the approved protocols should be submitted to the CEET before an award notice can be issued.
Applications must be submitted in a single PDF for internal review to firstname.lastname@example.org.
Complete applications must include the following:
1. Title of Application
2. Personnel information, name, position, title, and contact information
3. New format NIH Biosketch (5 pages)
4. List of Current and Pending grant support
5. An abstract (no more than 300 words)
6. A statement to indicate how this project would lead to extramural funding in the environmental health domain (not more than 1 page)
7. Specific aims (not more than 1 page)
8. Significance which must state relevance to environmental health
9. Preliminary studies
10. Methods (including statistical power and analysis)
11. A brief outline of how the results from the pilot study will enable the submission of a subsequent NIH grant and a detailed plan for this subsequent grant submission
**Items 8 to 11 should not exceed 5 pages
12. References; and
13. Budget – Items that can be requested include salary of support personnel, supplies and minor equipment. Travel is not allowed. Budget must be justified
Applications using Vertebrate Animals or Human Subjects must also submit the corresponding sections required in an NIH grant (see below) and failure to do so will lead to the application being not considered for funding.
1. Proposed Use of Animals
2. Justification for the Use of Animals
3. Veterinary Care
5. Method of euthanasi
1. Protection of Human Subjects
1.1. Human Subjects Involvement, Characteristics and Design
1.2. Adequacy of Protection Against Risks
1.3. Potential Benefits of the Proposed Human Research to Human Subjects and Others
1.4. Importance of Knowledge to be Gained
1.5. Data and Safety Monitoring Board
- Inclusion of Women and Minorities
- Targeted Planned Enrollment
- Inclusion of Children
All applications will be reviewed by a committee of CEET members and senior leadership and successful applicants will be notified by February 15 and will have a start date of March 1, 2018. For an award to be made all IACUC and IRB protocols must be in place.
Please email email@example.com with any questions.
The CEET is proud to announce the winners of the September 2016 competition:
Eric J. Brown, PhD
Associate Professor of Cancer Biology
Graphene-aptamer chemical sensors to detect toxins in water
A.T. Charlie Johnson, Ph.D.
Professor of Physics and Astronomy and Director, Nano/Bio Interface Center
Clementina Mesaros, PhD
Research Assistant Professor of Systems Pharmacology & Translational Therapeutics
Trevor M. Penning, PhD
Professor of Systems Pharmacology & Translational Therapeutics
Rebecca Simmons, MD
Previous Pilot Project Awards
Biomarkers of exposure to “Libby” asbestos
Edward Emmett, MD, MS
Professor of Occupational and Environmental Medicine
Department of Emergency Medicine
Hospital of the University of Pennsylvania
Particulate Matter Pollution in Philadelphia and its Association with Asthma Exacerbations
Blanca Himes, PhD
Assistant Professor of Epidemiology
Department of Biostatistics and Epidemiology
Sigrid Veasey, MD
Yanqing (Anna) Gong, PhD
Department of Medicine
Perelman School of Medicine
Mechanism and Function of Sleep Following Ultraviolet Radiation Induced Injury
David M. Raizen, M.D., Ph.D.
Department of Neurology
Perelman School of Medicine
Pilot Project Schedule
There are four types of pilot project applications:
- Mentored Scientist Transition Award (MSTA)
- Opportunity Award
- Focused Research Awards
- Inter-Environmental Health Sciences Core Center (inter-EHS CC) Pilots
Pilot-Project Eligibility Requirements by Award Type
|Mentored Scientist Transition Award||Opportunity Award||Focused Research Awards||inter- EHS CC Pilots*|
|Junior Faculty||Any faculty member||Any faculty member||Center Member|
|No previous federal grant support||Environmental health related research any field||Responsive to request for applications||Partner with a scientists at another EHS CC|
|Mentorship plan||First-time applicant preferred|
|Up to $50K per year for up to 2 years||Up to 50K||Varies||Up to 50K|
There are three Pilot-Project deadlines per year and applicants can apply for any award of their choice.
|Pilot-Project Competition Deadlines|
|Deadline||Review||Earliest Award Date|
|April 1||May||June 1|
|September 1||October||November 1|
|January 1||February||March 1|
All applicants are asked to submit a 10-page proposal irrespective of the type of award sought. The application must include: (a) Title of the Application; (b) personal information (name, position, title, affiliation, and contact information); (c) two-page NIH biosketch; (d) list of current and pending grant support; (e) an abstract: (f) a statement on how this project may lead to extramural funding in Environmental Health Sciences (EHS); (g) specific aims; (h) significance which must state the relevance to environmental health or toxicological research; (i) preliminary studies; (j) methods; (k) references; and (l) justified budget. The references and budget are not counted towards the page limitation. In addition, each award category has its own additional application requirements that do not count towards the page limitation.
Mentored Scientist Transition Award– The application must contain a letter from a faculty sponsor describing the mentorship plan and time-line to seek independent grant funding. If the junior investigator works in the faculty sponsor’s laboratory, the applicant must provide a copy of the mentor’s Other Support page and NIH biosketch to show that the proposal does not overlap with the sponsor’s funded research and is independent.
Opportunity Award in EHS- No additional information is required. But applications that use the CEET facility Cores: Integrative Health Sciences Facility Core, Translational Biomarker Core, or the CEET Informatics Core will be given strong consideration. In addition proposals that seek to answer an environmental health research question identified by the Community Outreach and Engagement Core are encouraged.
Focus Research Awards– The application must contain a paragraph indicating why it is responsive to the focus award area. Focused areas change based on intramural support from partner Departments, Centers and Institutes. Focused areas in the immediate future will be in epigenetics and Children’s Environmental Health and Disease Prevention. Applicants should contact the Center Administrator to determine which focused areas are being considered for funding in any given cycle.
Inter-Center EHS CC Pilot-Project- The application must contain at least one applicant from the CEET and another EHS CC. It must clearly state why the proposed work cannot be completed without the proposed collaboration. It must also contain a letter from the Director of the partnering EHS CC to indicate that they are willing to fund their portion of the project.
Mentored Scientist Transition Award (MSTA) applicants can request up to $40K per year for up to two years . All other categories can request up to $50K for a one year period.
Animals and Human Subjects
Applications that require the use of animals or human subjects must document that IACUC or IRB approval has been sought. All applications are submitted electronically to the CEET email address: firstname.lastname@example.org.
Clementina Mesaros, PhD
Over the last 2 years I developed scientific projects at the interface of clinical and basic science disciplines including: chemistry, toxicology, biochemistry and molecular biology. I have a broad background in bio-organic and bioanalytical chemistry reflected throughout my graduate and postdoctoral research. I am an expert with over 15 years of hands-on technical experience in liquid chromatography-mass spectrometry (LC-MS), which is the main bioanalytical tool used in the Translational Biomarker Core to measure bioactive small-molecules. I have developed and validated assays for metabolites involved in cellular oxidative stress using stable-isotope dilution LC-MS methods. I routinely generate progress reports and manuscripts containing details of these methodologies. In 2008, I was appointed Technical Director of the Biomarker Core Facility in the Center of Excellence in Environmental Toxicology, a P30 Environmental Health Sciences Core Center. In this role I manage the MS facility and maintain its day-to-day operation, supervise the technical support staff and ensure adequate quality control. I have collaborated extensively with Drs. Blair and Penning as well as junior scientists in their laboratories on using available assays and developing new ones.
Christopher Winterbottom, MD (MSTA)
My career goal is to become an independent clinical investigator with a focus on interstitial lung diseases including idiopathic pulmonary fibrosis (IPF), and the role that oxidative stress, including that caused by ambient particulate matter and other environmental pollutants, may play in its pathogenesis. The proposed research study aims to characterize the inflammatory response in subjects with idiopathic pulmonary fibrosis when challenged with diesel exhaust-induced oxidative stress. As a pulmonary and critical care fellow at the University of Pennsylvania, I have had extensive clinical experience in pulmonary and critical care medicine, including the care of a number of patients with IPF. This experience resulted in an appreciation for the challenges in caring for patients with such a poorly understood disease with such limited treatment options, and promoted a desire to pursue clinical research to further understand the pathogenesis of inflammatory lung diseases. My enrollment in the Master’s of Science in Clinical Epidemiology degree program at Penn has provided me with advanced training in epidemiologic and biostatistical methods, experience with protocol development and database management, and outstanding mentorship. These skills place me in an excellent position to work towards my career goals.